103772-14-1

Basic information

• Product Name: 5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid
• Synonyms: 5-Amino-1-cyclopropyl-1,4-dihydro-4-oxo-6,7,8-trifluoro-3-quinolinecarboxyl;5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid;5-amino-1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;Sparfloxacin Impurity 2
• CAS NO: 103772-14-1
• Molecular Formula: C₁₃H₉F₃N₂O₃
• Molecular Weight: 298.2173696
• Mol File: 103772-14-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 512.4°Cat760mmHg
• Flash Point: 263.7°C
• Appearance: /
• Density: 1.762g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.68
• CAS DataBase Reference: 5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid(103772-14-1)
• EPA Substance Registry System: 5-Amino-l-Cyclopropyl-6,7, 8-Trifluoro-1,4-Dihydro-4-Oxo-3-Quinolinearboxylic Acid(103772-14-1)

Safety Data

• Hazardous Substances Data: 103772-14-1(Hazardous Substances Data)

Usage

Uses

5-Amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid is an impurity of?Sparfloxacin (S679250), a?fluorianted quinolone antibacterial.

InChI:InChI=1/C13H9F3N2O3/c14-7-8(15)10(17)6-11(9(7)16)18(4-1-2-4)3-5(12(6)19)13(20)21/h3-4H,1-2,17H2,(H,20,21)

Upstream product

• 103772-13-0 ethyl 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 107564-01-2 ethyl 3-cyclopropylamino-2-pentafluorobenzoyl acrylate 
• 114226-95-8 ethyl-2-ethoxymethylene-3-oxo-3-pentafluorophenylpropionate 
• 3516-87-8 ethyl 2,3,4,5,6-pentafluorobenzoylacetate 
• 2251-50-5 pentafluorobenzoylchloride 
• 602-94-8 Pentafluorobenzoic acid 
• 107564-02-3 1-cyclopropyl-5,6,7,8-tetrafluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid,ethyl ester 
• 104885-01-0 ethyl α-(ethoxymethylene)-2,3,4,5-tetrafluoro-6-nitro-β-oxobenzenepropanoate 
• 103772-11-8 2-nitro-3,4,5,6-tetrafluoro-β-oxobenzenepropanoic acid,ethyl ester 
• 103772-10-7 2,3,4,5-tetrafluoro-6-nitro-benzoyl chloride 
• 16583-08-7 2,3,4,5-tetrafluoro-6-nitrobenzoic acid 
• 1201-31-6 2,3,4,5-tetrafluorobenzoic acid 
• 103772-12-9 ethyl 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-5-nitro-4-oxo-3-quinolinecarboxylate 
• 110872-04-3 ethyl 5-(benzylamino)-1-cyclopropyl-6,7,8-trifluoro-4(1H)-oxoquinoline-3-carboxylate 

Downstream Products

• 120379-32-0 5-Amino-1-cyclopropyl-6,8-difluoro-7-((R)-3-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 110871-85-7 5-amino-1-cyclopropyl-6,8-difluoro-7-(3-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 111542-93-9 5-amino-1-cyclopropyl-7-(3,5-dimethyl-piperazin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 110871-86-8 sparfloxacin 
• 110871-98-2 Ethyl 5-amino-1-cyclopropyl-6,8-difluoro-7-(3-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 143699-74-5 5-Amino-1-cyclopropyl-6,8-difluoro-7-[3-(4-Phenyl-1,2,3-triazol-1-yl)pyrrolidin-1-yl]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 150281-66-6 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-[3-[4-[(methylamino)methyl]phenyl]-1-pyrrolidinyl]-4-oxo-3-quinolinecarboxylic acid 
• 150281-62-2 5-amino-7-[3-[4-(aminomethyl)phenyl]-1-pyrrolidinyl]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
• 150281-54-2 5-amino-7-[3-[2-(aminomethyl)phenyl]-1-pyrrolidinyl]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
• 124256-02-6 5-amino-7-(2-aminoethyl)thio-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 112654-98-5 5-amino-7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 

Relevant articles and documents

QUINOLIN-4-ONE AND 4(1H)-CINNOLINONE COMPOUNDS AND METHODS OF USING SAME

The present disclosure relates to quinolin-4-one and 4(1H)-cinnolinone compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.

Aminoquinolones as GSK-3 inhibitors

Provided herein are aminoquinolones and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating, preventing or ameliorating GSK-3 mediated diseases.

Quinoline derivatives and processes for preparation thereof

The present invention relates to a quinoline derivative of the formula wherein Z is an amino group or a halogen atom, R1 is a hydrogen atom or a methyl or ethyl group, R2 is a hydrogen atom or a methyl or fluoromethyl group, R3 and R4 are the same or different and each represents a hydrogen atom or a methyl group, and n is 1 or 2; and esters thereof and salts thereof and processes for preparation thereof. These compounds show excellent antibacterial activity and are useful antibacterial agents