1037797-53-7

Basic information

• Product Name: 4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(piperidin-4-yl)thiazole
• Synonyms: 4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(piperidin-4-yl)thiazole
• CAS NO: 1037797-53-7
• Molecular Weight: 342.425
• Mol File: 1037797-53-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(piperidin-4-yl)thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(piperidin-4-yl)thiazole(1037797-53-7)
• EPA Substance Registry System: 4-((4-(1H-tetrazol-1-yl)phenoxy)methyl)-2-(piperidin-4-yl)thiazole(1037797-53-7)

Safety Data

• Hazardous Substances Data: 1037797-53-7(Hazardous Substances Data)

Upstream product

• 1037791-31-3 4-[4-(4-tetrazol-1-ylphenoxymethyl)thiazol-2-yl]piperidine-1-carboxylic acid tert-butyl ester 
• 39546-32-2 4-carboxamidopiperidine 

Downstream Products

• 1037793-42-2 4-[4-(4-tetrazol-1-ylphenoxymethyl)thiazol-2-yl]piperidine-1-carboxamidine 
• 1044136-60-8 4-[4-(4-tetrazol-1-ylphenoxymethyl)thiazol-2-yl]piperidine-1-carbonitrile 
• 1037792-44-1 5-ethyl-2-{4-[4-({[4-(1H-tetrazol-1-yl)phenyl]oxy}methyl)-1,3-thiazol-2-yl]-1-piperidinyl}pyrimidine 
• 1037793-40-0 4-[4-(4-tetrazol-1-ylphenoxymethyl)thiazol-2-yl]piperidine-1-carboxylic acid amide 
• 1037793-31-9 1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-4-[4-(4-tetrazol-1-ylphenoxymethyl)thiazol-2-yl]piperidine 

Relevant articles and documents

Synthesis and biological evaluation of thiazole derivatives as GPR119 agonists

A series of 4-(phenoxymethyl)thiazole derivatives was synthesized and evaluated for their GPR119 agonistic effect. Several 4-(phenoxymethyl)thiazoles with pyrrolidine-2,5-dione moieties showed potent GPR119 agonistic activities. Among them, compound 27 and 32d showed good in vitro activity with an EC50 value of 49 nM and 18 nM, respectively with improved human and rat liver microsomal stability compare with MBX-2982. Compound 27 & 32d did not exhibit significant CYP inhibition, hERG binding, and cytotoxicity. Moreover, these compounds lowered the glucose excursion in mice in an oral glucose-tolerance test.

PREPARATION OF 5-ETHYL-2-{4-[4-(4-TETRAZOL-1-YL-PHENOXYMETHYL)-THIAZOL-2-YL]-PIPERIDIN-1-YL}-PYRIMIDINE

Processes and intermediates for the synthesis of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine are provided.