103846-35-1Relevant articles and documents
Synthesis of 2,7-disubstituted-5,6-dimethylpyrrolo-[2,3-d]-1,3-oxazin-4- ones as antifungal agents
Player,Sowell Sr.
, p. 209 - 214 (2007/10/02)
A series of novel 5,6-dimethylpyrrolo[2,3-d]-1,3-oxazin-4-ones were synthesized from 2-amino-3-tert-butoxy-carbonyl-4,5-dimethylpyrroles. Two methods were used, cyclodehydration of 2-acylamino-3-carboxypyrroles with acetic anhydride and direct conversion of the 5,6-dimethylpyrrolo[2,3-d]- 1,3-oxazin-2,4-diones to the title compounds with an anhydride directly providing the 2 substituent. Molecular modeling techniques revealed that these pyrrolo[2,3-d]oxazinones were rigid analogues of the allylamine antifungals. The compounds were tested for in vitro activity against Tricophyton and Scopulariopsis sp.
Synthesis of 7-Substituted 5,6-Dimethyl-2,4-dioxo-1,2,4,7-tetrahydropyrrolooxazines
Ross, John R.,Laks, JoAnn S.,Wang, Daniel Li-Chang,Sowell, J. Walter
, p. 796 - 798 (2007/10/02)
The title compounds 2 are prepared by the cyclization of substituted pyrroles 3 with phosgene in refluxing tetrahydrofuran.In the case of 3a, it is shown that the cyclization can also be achieved after alkylation to give 8.
