1038594-01-2 Usage
Uses
Used in Scientific Research and Development:
(R)-2-Amino-1-(pyridin-3-yl)ethanol hydrochloride is utilized as a key intermediate in the synthesis of various pharmaceuticals and bioactive molecules. Its unique structural features, including the pyridine ring, hydroxy, and amino groups, enable it to form stable complexes with target molecules, making it a valuable building block in medicinal chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (R)-2-Amino-1-(pyridin-3-yl)ethanol hydrochloride serves as a chiral auxiliary or ligand in asymmetric synthesis, facilitating the production of enantiomerically pure compounds. Its stereochemistry plays a crucial role in determining the biological activity and selectivity of the resulting pharmaceuticals, ensuring optimal therapeutic effects and minimizing side effects.
Used in Chemical Reactions:
(R)-2-Amino-1-(pyridin-3-yl)ethanol hydrochloride is employed as a reactant or catalyst in various organic reactions, such as condensation, substitution, and rearrangement processes. Its hydrochloride form enhances its reactivity, allowing it to participate in a wide range of chemical transformations, contributing to the synthesis of complex organic molecules and materials.
Used in Analytical Chemistry:
(R)-2-Amino-1-(pyridin-3-yl)ethanol hydrochloride can be utilized as a chiral selector in chromatographic and electrophoretic techniques for the separation and analysis of enantiomers. Its unique stereochemistry enables the differentiation of chiral compounds, providing valuable insights into their structural and functional properties.
Check Digit Verification of cas no
The CAS Registry Mumber 1038594-01-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,8,5,9 and 4 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1038594-01:
(9*1)+(8*0)+(7*3)+(6*8)+(5*5)+(4*9)+(3*4)+(2*0)+(1*1)=152
152 % 10 = 2
So 1038594-01-2 is a valid CAS Registry Number.
1038594-01-2Relevant academic research and scientific papers
Duquette, Jason,Zhang, Mingbao,Zhu, Lei,Reeves, Raymond S.
, p. 285 - 288 (2003)
This report describes a scalable process for the asymmetric synthesis of (R)-2-amino-1-(3-pyridinyl)ethanol dihydrochloride. The stereochemistry of the product is set via a reduction of 3-chloroacetyl pyridine with 2 equiv of borane-dimethyl sulfide and a catalytic amount of an in situ generated oxazaborolidine. The enantiomeric excess (ee) of the reductive step depends on the addition rate of the substrate and the temperature. The authors hypothesize that the low ee observed during a fast addition of the substrate or at low temperatures is due to the slow regeneration of the active catalyst from the catalyst-product complex.
NOVEL SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA-3 ADRENORECEPTOR AGONISTS
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Page/Page column 59, (2008/12/07)
This invention relates to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.
SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA 3 ADRENORECEPTOR AGONISTS
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, (2011/11/14)
This invention related to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.
