61889-48-3

Usage

Uses

Used in Pharmaceutical Synthesis:
3-(2-Chloroacetyl)pyridine hydrochloride is used as a synthetic intermediate for the preparation of chiral amino(pyridinyl)ethanol. 3-(2-Chloroacetyl)pyridine hydrochloride is crucial in the development of enantiomerically pure pharmaceuticals, which are essential for ensuring the desired therapeutic effects and minimizing potential side effects associated with racemic mixtures.
Used in Enzymatic Kinetic Resolution:
3-(2-Chloroacetyl)pyridine hydrochloride is utilized in the lipase-mediated kinetic resolution process. This enzymatic approach allows for the selective transformation of one enantiomer over the other, leading to the production of chiral amino(pyridinyl)ethanol with high enantioselectivity and yield. This method is particularly valuable in the pharmaceutical industry, where the synthesis of enantiomerically pure compounds is of utmost importance for drug development and safety.

InChI:InChI=1/C7H6ClNO/c8-4-7(10)6-2-1-3-9-5-6/h1-3,5H,4H2

Upstream product

• 39972-50-4 2-diazo-1-(pyridine-3-yl)ethan-1-one 
• 59-67-6 nicotinic acid 
• 10400-19-8 3-pyridinecarbonyl chloride 
• 350-03-8 methyl-3-pyridylketone 
• 67210-10-0 nicotinoyl chloride hydrochloride 

Downstream Products

• 515179-33-6 (S)-2-chloro-1-(pyridin-3-yl)ethanol 
• 173901-03-6 (R)-2-chloro-1-(3-pyridyl)-ethanol 
• 55484-11-2 2-chloro-1-(pyridin-3-yl)ethan-1-one 
• 1038594-01-2 (1R)-2-amino-1-(3-pyridinyl)ethanol dihydrochloride 

Relevant academic research and scientific papers

NOVEL SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA-3 ADRENORECEPTOR AGONISTS

This invention relates to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.

METHOD FOR THE PRODUCTION OF A-CHLOROALKYLPYRIDYL KETONES AND/OR THE HYDROCHLORIDES THEREOF

A method for the production of unsubstituted or nuclear substituted a-chloroalkylpyridyl ketones and/or the hydrochlorides thereof by reacting the corresponding unsubstituted or nuclear substituted alkylpyridyl ketone hydrochlorides with sulfuryl chloride at a reaction temperature of -25 to 70 °C (248 - 343 K) and a pressure of 0.05 0.2 MPa abs, wherein the reaction is carried out in the presence of a non-branched or branched, unsubstituted C1- C10 alkanic acid or C1- C10 alkanic acid which is monosubstituted or fully substituted with a radical selected from the group consisting of fluorine, chlorine and bromine, whose melting point is lower than the selected reaction temperature.

A scalable asymmetric synthesis of (R)-2-amino-1-(3-pyridinyl)ethanol dihydrochloride via an oxazaborolidine catalyzed borane reduction

This report describes a scalable process for the asymmetric synthesis of (R)-2-amino-1-(3-pyridinyl)ethanol dihydrochloride. The stereochemistry of the product is set via a reduction of 3-chloroacetyl pyridine with 2 equiv of borane-dimethyl sulfide and a catalytic amount of an in situ generated oxazaborolidine. The enantiomeric excess (ee) of the reductive step depends on the addition rate of the substrate and the temperature. The authors hypothesize that the low ee observed during a fast addition of the substrate or at low temperatures is due to the slow regeneration of the active catalyst from the catalyst-product complex.

Carboxyl substituted chroman derivatives useful as beta 3 adrenoreceptor agonists

This invention is related to novel carboxyl substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.

CARBOXYL SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA 3 ADRENORECEPTOR AGONISTS

This invention is related to novel carboxyl substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.

SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA 3 ADRENORECEPTOR AGONISTS

This invention related to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.

SUBSTITUTED SULFONAMIDES AS SELECTIVE BETA-3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY

Substituted sulfonamides are selective β 3 adrenergic receptor agonists with very little β 1 and β 2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent

SUBSTITUTED SULFONAMIDES AS SELECTIVE BETA3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY

Substituted sulfonamides are selective β 3 adrenergic receptor agonists with very little β 1 and β 2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent