10386-19-3

Upstream product

• 2009-24-7 8-hydroxypsoralen 
• 108-24-7 acetic anhydride 
• 482-44-0 imperatorin 
• 298-81-7 9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one 
• 75-36-5 acetyl chloride 

Downstream Products

• 42207-40-9 9-(phenylmethoxy)-7H-furo[3,2-g][1]benzopyran-7-one 
• 83934-65-0 8-ethoxypsoralen 
• 482-44-0 imperatorin 
• 298-81-7 9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one 

Relevant academic research and scientific papers

STEROIDS, CHROMONE AND COUMARINS FROM ANGELICA OFFICINALIS

From the ethyl acetate extract of the fresh roots of Angelica officinalis var. himaliaca, besides sitosterol, pregnenolone, peucenin-7-methyl ether, osthol and 18 furanocoumarins have been characterized by spectroscopic methods, including 13C NMR, and some chemical transformations. - Keywords: Angelica officinalis; Umbelliferae; root; pregnenolone; sitosterol; osthol; peucenin-7-methyl ether; furanocoumarins.

CHROMONES AND COUMARINS FROM SKIMMIA LAUREOLA

The isolation and characterisation of chromones and coumarins, including the new chromone, skimminin, from S. laureola is reported. - Key Word Index: Skimmia laureola; Rutaceae; chromones; skimminin; coumarins; linear furanocoumarins.

Structural modifier of 8-methoxypsoralen as well as preparation method and application of structural modifier

The invention discloses a structural modifier of 8-methoxypsoralen as well as a preparation method and application of the . The structural modifier of the 8-methoxypsoralen provided by the invention is a compound B20 shown as a formula 1 or a compound A10 shown as a formula 2. The bacteriostatic activity of the compound B20 for enterotoxigenic escherichia coli at the concentration of 64 mu g/mL is2.3 times of that of the 8-methoxypsoralen; the bacteriostatic activity of the compound A10 for enterotoxigenic escherichia coli at the concentration of 64 mu g/mL is 2.4 times of the 8-methoxypsoralen. The compound B20 and the compound A10 can be applied to the preparation of a medicament for treating and/or preventing piglet diarrhea. The formula 1 and the formula 2 are shown in the description.

Structural modification of a specific antimicrobial lead against Helicobacter pylori discovered from traditional Chinese medicine and a structure-activity relationship study

Psoralen (1a) was found to be a specific and potent antimicrobial lead against Helicobacter pylori (H. pylori) from a traditional Chinese medicine (TCM) in the bioassay directed isolation. A series of structurally diverse analogues of 1a were thus designed and synthesized to improve the antimicrobial potency, some of which showed more potent activities than the lead compound (1a) against H. pylori. Among them, compound 25a is 16-fold stronger (MIC = 0.39 μg/mL) than 1a (MIC = 6.25 μg/mL), and is even potent than the positive control metronidazole (MIC = 0.50 μg/mL). The in vitro antimicrobial activities against H. pylori of these structurally diverse analogues based on the scaffold of 1a have also led to an outline of structure-activity relationship.