42207-40-9Relevant articles and documents
Synthesis of imperatorin analogs and their evaluation as acetylcholinesterase and butyrylcholinesterase inhibitors
Granica, Sebastian,Kiss, Anna K.,Jaronczyk, Malgorzata,Maurin, Jan K.,Mazurek, Aleksander P.,Czarnocki, Zbigniew
, p. 775 - 782 (2013)
In this study, we synthesized several imperatorin analogs using imperatorin and xanthotoxin as substrates. The anti-cholinesterase activities of all compounds were evaluated in in vitro experiments according to the modified Ellman's method. For each synthesized compound, IC50 values for both enzymes were established. Galantamine hydrobromide was used as a positive control in the enzymatic experiments. All active compounds showed selectivity toward butyrylcholinesterase (BuChE) rather than acetylcholinesterase. The most active ones were 8-(3-methylbutoxy)-psoralen and 8-hexoxypsoralen with IC 50 values for BuChE of around 16.5 and 16.4 μM, respectively. The results of our study may be considered as the beginning of a search for potential anti-Alzheimer's disease drugs based on the structure of natural furocoumarins. Several imperatorin analogs were synthesized using imperatorin and xanthotoxin as substrates. Their anti-cholinesterase activities were evaluated, and all active compounds showed selectivity toward butyrylcholinesterase (BuChE) rather than acetylcholinesterase. The most active compounds were 8-(3-methylbutoxy)-psoralen and 8-hexoxypsoralen with IC 50 values for BuChE of around 16.5 and 16.4 μM, respectively.
Synthesis and antidepressant-like action of 9-alkoxy-7H-furo[3,2-g]chromen- 7-ones in mice
Deng, Xian-Qing,Wei, Cheng-Xi,Song, Ming-Xia,Quan, Zhe-Shan
, p. 587 - 592 (2011/05/11)
The present study describes the chemical synthesis and pharmacological evaluation of a series of 9-alkoxy-7H-furo[3,2-g]-chromen-7-ones. The pharmacological results of these compounds show that nine of them, given orally, reduced the immobility time in the forced swimming test. The results of the open-field test further confirmed that these compounds possessed an antidepressant-like effect. In the 5-hydroxytryptophan induced head-twitch test, 9-(3-chlorobenzyloxy)-7H-furo[3,2-g]chromen-7-one (3m, 40 mg/kg p.o.) significantly increased the cumulative number of head twitches. This finding suggested that the antidepressant-like profile seems to involve the serotonergic system as underlying mechanism. ECV · Editio Cantor Verlag.
A Simple One-step Synthesis of Phenyl Ethers from Phenyl Acetates
Banerjee, Sunil K.,Gupta, Bishan D.,Singh, Kuber
, p. 815 - 816 (2007/10/02)
Phenyl acetates when refluxed with alkyl halides in acetone solution in the presence of a crown ether and anhydrous potassium carbonate undergo alkylation yielding phenyl ethers.
