103889-84-5

Basic information

• Product Name: (R)-2-METHOXY-PHENYLGLYCINE
• Synonyms: (R)-AMINO-(2-METHOXY-PHENYL)-ACETIC ACID;(R)-2-METHOXY-PHENYLGLYCINE;AMINO-(2-METHOXY-PHENYL)-ACETIC ACID;(R)-2-AMino-2-(2-Methoxyphenyl)acetic acid;(R)-2-Methoxyphenylglycine≥ 99% (HPLC, Chiral purity)
• CAS NO: 103889-84-5
• Molecular Formula: C9H11NO3
• Molecular Weight: 181.19
• EINECS: 604-604-1
• Product Categories: Unusual amino acids
• Mol File: 103889-84-5.mol

Chemical Properties

• Boiling Point: 343.9°C at 760 mmHg
• Flash Point: 161.8°C
• Appearance: /
• Density: 1.246g/cm³
• Vapor Pressure: 2.6E-05mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (R)-2-METHOXY-PHENYLGLYCINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-METHOXY-PHENYLGLYCINE(103889-84-5)
• EPA Substance Registry System: (R)-2-METHOXY-PHENYLGLYCINE(103889-84-5)

Safety Data

• Hazardous Substances Data: 103889-84-5(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C9H11NO3/c1-13-7-5-3-2-4-6(7)8(10)9(11)12/h2-5,8H,10H2,1H3,(H,11,12)

Upstream product

• 77651-54-8 5-(2-methoxyphenyl)imidazolidine-2,4-dione 
• 271583-23-4 2-(benzylamino)-2-(2-methoxyphenyl)acetic acid 
• 339274-27-0 (R)-2,2,2-trichloro-1-(2-methoxyphenyl)ethanol 
• 284687-65-6 2,2,2-trichloro-1-(2-methoxyphenyl)ethanone 
• 135-02-4 ortho-anisaldehyde 
• 58369-59-8 2-methoxy-α-(trichloromethyl)benzyl alcohol 
• 77651-55-9 2-methoxy phenylglycine methyl ester 
• 271583-39-2 2-(benzylamino)-2-(2-methoxyphenyl)acetamide 
• 271583-59-6 2-(benzylamino)-2-(2-methoxyphenyl)acetonitrile 

Downstream Products

• 77651-56-0 methyl (+/-)-2-methoxy-α-<(thioxomethyl)amino>benzene acetate 
• 77651-57-1 (2-Methoxy-phenyl)-methylsulfanylmethyleneamino-acetic acid methyl ester 

Relevant articles and documents

ISOINDOLIN-1-ON DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE COMPONENT FOR PREVENTING OR TREATING CANCER

The present invention relates to an isoindolin-1-one derivative, a method for preparing the same, and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating cancer, wherein the isoindolin-1-one derivative exhib

Synthesis of Unprotected 2-Arylglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine

The transamination of α-keto acids with 2-phenylglycine is an effective methodology for directly synthesizing unprotected α-amino acids. However, the synthesis of 2-arylglycines by transamination is problematic because the corresponding products, 2-arylglycines, transaminate the starting arylglyoxylic acids. Herein, we demonstrate the use of commercially available l-2-(2-chlorophenyl)glycine as the nitrogen source in the transamination of arylglyoxylic acids, producing the corresponding 2-arylglycines without interference from the undesired self-transamination process.

A practical asymmetric synthesis of homochiral α-arylglycines

Enantioselective reduction of a series of substituted aryl trichloromethyl ketones with the CBS-catecholborane reagent afforded homochiral aryl trichloromethyl carbinols which have been elaborated to give homochiral α-arylglycines in high e.e.

A facile synthesis of substituted phenylglycines

A convenient scaleable process for the preparation of substituted phenylglycines 2 by a modified Strecker reaction is described. Bisulfite- mediated addition of benzylamine and cyanide anion to substituted benzaldehydes 3 gave the aminonitriles 4 which were hydrolysed in two steps to the N-protected amino acid 1. Debenzylation using catalytic transfer hydrogenation gave the title compounds in good yield.