1038925-00-6

Basic information

• Product Name: (3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one
• Synonyms: (3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one
• CAS NO: 1038925-00-6
• Molecular Weight: 265.355
• Mol File: 1038925-00-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one(1038925-00-6)
• EPA Substance Registry System: (3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one(1038925-00-6)

Safety Data

• Hazardous Substances Data: 1038925-00-6(Hazardous Substances Data)

Usage

Uses

Sacubitril Impurity 3 is an impurity of Sacubitril (S080895) which is an antihypertensive drug used in combination with valsartan.

Upstream product

• 1174131-32-8 (3R/S,5S)-5-biphenyl-4-ylmethyl-3-iodomethyl-pyrrolidin-2-one 
• 1038925-08-4 (3R,5R)-5-(biphenyl-4-yl)methyl-3-methyl-2-oxopyrrolidine-3-carboxylic acid 
• 1038925-09-5 (3S,5R)-5-biphenyl-4-ylmethyl-3-methyl-2-oxopyrrolidine-3-carboxylic acid 
• 149690-13-1 ethyl (2S,4S)-4-amino-5-[(1,1'-biphenyl)-4-yl]-2-methylpentanoate hydrochloride 
• 149690-12-0 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride 
• 1038924-61-6 (S)-5-biphenyl-4-ylmethylpyrrolidin-2-one 
• 74-88-4 methyl iodide 

Downstream Products

• 1038924-66-1 (3R,5S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-methylpyrrolidin-2-one 
• 1038924-67-2 (3S,5S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-methylpyrrolidin-2-one 

Relevant articles and documents

NEW PROCESSES

The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.