(3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one

Base Information

Chemical Name:(3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one
CAS No.:1038925-00-6
Molecular Formula:C₁₈H₁₉NO
Molecular Weight:265.355
Hs Code.:

Synonyms:(3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one

Suppliers and Price of (3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
SacubitrilImpurity3
1mg
$ 130.00

Total 13 raw suppliers

Chemical Property of (3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

SacubitrilImpurity3 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Sacubitril Impurity 3 is an impurity of Sacubitril (S080895) which is an antihypertensive drug used in combination with valsartan.

Technology Process of (3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one

There total 4 articles about (3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1174131-32-8
(3R/S,5S)-5-biphenyl-4-ylmethyl-3-iodomethyl-pyrrolidin-2-one

: 1038925-00-6
(3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one

: 1038924-70-7
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Guidance literature:: With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; at 20 ℃; under 750.075 Torr;

Reference yield:

: 1038924-61-6
(S)-5-biphenyl-4-ylmethylpyrrolidin-2-one

: 74-88-4
methyl iodide

: 1038925-00-6
(3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one

: 1038924-70-7
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Guidance literature:: (S)-5-biphenyl-4-ylmethylpyrrolidin-2-one; With n-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 0.5h; Heating / reflux;

methyl iodide; In tetrahydrofuran; cyclohexane; at -78 ℃; for 2h; Product distribution / selectivity;

Reference yield:

: 149690-13-1
ethyl (2S,4S)-4-amino-5-[(1,1'-biphenyl)-4-yl]-2-methylpentanoate hydrochloride

: 149690-12-0
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride

: 1038925-00-6
(3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one

: 1038924-70-7
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Guidance literature:: ethyl (2S,4S)-4-amino-5-[(1,1'-biphenyl)-4-yl]-2-methylpentanoate hydrochloride; (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride; With triethylamine; In Isopropyl acetate; at 55 ℃; for 1h;

In Isopropyl acetate; for 24h; Product distribution / selectivity; Heating / reflux;