103956-10-1 Usage
Description
2,4-dimethoxybenzohydrazide, a hydrazide derivative of 2,4-dimethoxybenzoic acid with the molecular formula C9H12N2O3, is a chemical compound that has garnered attention for its potential applications in various fields. Its unique structure, featuring two methoxy groups at the 2,4 positions of the benzene ring, endows it with versatile chemical properties, making it a valuable building block in the synthesis of a wide array of compounds.
Uses
Used in Pharmaceutical Industry:
2,4-dimethoxybenzohydrazide is utilized as a key building block for the synthesis of various pharmaceutical compounds. Its ability to form diverse chemical entities through its reactive functional groups makes it a promising candidate for the development of new drugs with potential therapeutic applications.
Used in Agricultural Industry:
In the agricultural sector, 2,4-dimethoxybenzohydrazide serves as a vital component in the synthesis of agrochemicals, including pesticides and herbicides. Its versatility in chemical reactions allows for the creation of compounds that can effectively target and control pests and weeds, thereby enhancing crop productivity and yield.
Used as a Reagent in Organic Synthesis:
2,4-dimethoxybenzohydrazide is employed as a reagent in organic synthesis, where it facilitates the formation of complex organic molecules. Its presence in reactions can lead to the production of a variety of organic compounds with different functional groups, expanding the scope of organic chemistry.
Used as a Precursor for Heterocyclic Compounds:
2,4-dimethoxybenzohydrazide also acts as a precursor for the preparation of heterocyclic compounds, which are an essential class of organic compounds with diverse applications in pharmaceuticals, materials science, and other fields. The synthesis of heterocyclic compounds from 2,4-dimethoxybenzohydrazide can lead to the discovery of new compounds with unique properties and potential applications.
Used in Biological and Pharmacological Research:
2,4-dimethoxybenzohydrazide has been studied for its potential biological and pharmacological activities. Its derivatives have demonstrated a range of properties, including antimicrobial, antifungal, and anticancer activities, making it a valuable compound for further research and development in the field of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 103956-10-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,9,5 and 6 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 103956-10:
(8*1)+(7*0)+(6*3)+(5*9)+(4*5)+(3*6)+(2*1)+(1*0)=111
111 % 10 = 1
So 103956-10-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H12N2O3/c1-13-6-3-4-7(9(12)11-10)8(5-6)14-2/h3-5H,10H2,1-2H3,(H,11,12)
103956-10-1Relevant articles and documents
Synthesis of new oxadiazole derivatives as α-glucosidase inhibitors
Taha, Muhammad,Ismail, Nor Hadiani,Imran, Syahrul,Rokei, Muhammad Qamarruddin Bin,Saad, Syed Muhammad,Khan, Khalid Mohammed
, p. 4155 - 4162 (2015)
Oxadiazole derivatives (6-28) having hydrazone linkage, were synthesized through condensation reaction between benzohydrazide 5 with various benzaldehydes. The oxadiazoles derivatives (6-28) were evaluated for their α-glucosidase inhibitory activity. The IC50 values for inhibition activity vary in the range between 2.64 ± 0.05 and 460.14 ± 3.25 μM. The IC50 values were being compared to the standard acarbose (IC50 = 856.45 ± 5.60 μM) and it was found that compounds 6-9, 12, 13, 16, 18, 20, 22-28 were found to be more active than acarbose, while other compounds showed no activity. Structure-activity relationship (SAR) studies suggest that oxadiazole benzohydrazones (6-28) inhibitory potential is dependent on substitution of the N-benzylidene part. Compound 18 (IC50 = 2.64 ± 0.05 μM), which has trihydroxy substitution at C-2′, C-4′, and C-5′ on N-benzylidene moiety, recorded the highest inhibition activity that is three-hundred times more active than the standard drug, acarbose (IC50 = 856.45 ± 5.60 μM). Compound 23 (IC50 = 34.64 ± 0.35 μM) was found to be the most active among compounds having single hydroxyl substitution. Shifting hydroxyl from C-2′ to C-4′ (6) and C-3′ (7) reduces inhibitory activity significantly. Compounds with chlorine substituent (compounds 16, 28, and 27) showed potent activities but lower as compared to hydroxyl analogs. Substituent like nitro or methyl groups at any position suppresses enzyme inhibition activity. This reveals the important presence of hydroxyl and halo groups to have enzyme inhibitory potential.
Identification of a potent new chemotype for the selective inhibition of PDE4
Skoumbourdis, Amanda P.,Huang, Ruili,Southall, Noel,Leister, William,Guo, Vicky,Cho, Ming-Hsuang,Inglese, James,Nirenberg, Marshall,Austin, Christopher P.,Xia, Menghang,Thomas, Craig J.
, p. 1297 - 1303 (2008/09/20)
A series of substituted 3,6-diphenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines were prepared and analyzed as inhibitors of phosphodiesterase 4 (PDE4). Synthesis, structure-activity relationships, and the selectivity of a highly potent analogue against related phosphodiesterase isoforms are presented.
Triazole derivatives
-
, (2011/03/17)
The present invention relates to triazole and imidazole derivatives of formula I and to their pharmaceutically acceptable acid addition salts. These compounds are NMDA receptor subtype blockers and are useful for the treatment of diseases related to the NMDA receptor.
