1039762-40-7

Basic information

• Product Name: O-Methyl Ether OlMesartan Acid
• Synonyms: O-Methyl Ether OlMesartan Acid;1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-methoxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid;4-(1-Methoxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid;GAQUHNKHOZJBIJ-UHFFFAOYSA-N
• CAS NO: 1039762-40-7
• Molecular Formula: C₂₅H₂₈N₆O₃
• Molecular Weight: 460.52822
• Product Categories: Aromatics, Heterocycles, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1039762-40-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: DMSO, Methanol
• CAS DataBase Reference: O-Methyl Ether OlMesartan Acid(CAS DataBase Reference)
• NIST Chemistry Reference: O-Methyl Ether OlMesartan Acid(1039762-40-7)
• EPA Substance Registry System: O-Methyl Ether OlMesartan Acid(1039762-40-7)

Safety Data

• Hazardous Substances Data: 1039762-40-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 1039762-40-7 differently. You can refer to the following data:
1. O-Methyl Ether Olmesartan Acid is an impurity of Olmesartan Acid (O550001), an detritylated derivative of of Olmesartan Medoxomil (O550000), an angiotensin II receptor antagonist.
2. O-Methyl Ether Olmesartan Acid is an impurity of Olmesartan Acid (O550001), an detritylated derivative of Olmesartan Medoxomil (O550000), an angiotensin II receptor antagonist.

Upstream product

• 1849-29-2 1,1,1-trideuteromethanol 
• 144689-63-4 olmesartan medoxomil 
• 67-56-1 methanol 
• 1039762-39-4 ethyl-4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-trityltetrazol-5-yl)phenyl}phenylmethylimidazole-5-carboxylate 

Relevant articles and documents

A convenient and practical synthesis of olmesartan medoxomil methyl ether

Synthesis of Olmesartan medoxomil methyl ether (2), a potential impurity of Olmesartan medoxomil (1), an angiotensin II receptor blockers is reported for the first time.

An efficient synthetic method and theoretical calculations of olmesartan methyl ether: Study of biological function of AT1 antagonism

The dissolution of the antihypertensive AT1 antagonist olmesartan in methanol generates in situ a new highly bioactive methyl ether analogue via SN1 mechanism involving an intramolecular proton transfer from carboxyl to hydroxyl group. Theoretical calculations confirmed the thermodynamic control preference of methyl ether versus the antagonistic product methyl ester. ? facile synthetic method for olmesartan methyl ether from olmesartan or olmesartan medoxomil is also described. Interestingly, the introduction of the methyl group to olmesartan did not alter its pharmacological properties. This observation opens new avenues in the synthesis of novel drugs, since hydroxyl and carboxylate groups have an orthogonal relationship in many drugs.