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[2-(1-benzyl-1H-indazol-3-yloxy)-ethyl]-dimethyl-amine is a complex organic compound with the molecular formula C20H22N2O. It is characterized by a benzyl group attached to an indazole ring, which is further connected to an ethyloxyethyl chain that terminates in a dimethylamine group. [2-(1-benzyl-1H-indazol-3-yloxy)-ethyl]-dimethyl-amine is of interest in medicinal chemistry, particularly in the development of potential therapeutic agents, due to its unique structure that can interact with biological targets. The benzyl-indazole moiety is known for its ability to form stable complexes with various proteins, while the ethyloxyethyl-dimethylamine segment may contribute to the compound's solubility and pharmacokinetic properties. The specific arrangement of these functional groups allows for the exploration of its potential applications in drug design, where it may be used to modulate specific biological pathways or target certain receptors.

1040-07-9

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1040-07-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1040-07-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,4 and 0 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1040-07:
(6*1)+(5*0)+(4*4)+(3*0)+(2*0)+(1*7)=29
29 % 10 = 9
So 1040-07-9 is a valid CAS Registry Number.

1040-07-9Downstream Products

1040-07-9Relevant academic research and scientific papers

Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase

Selwood,Brummell,Budworth,Burtin,Campbell,Chana,Charles,Fernandez,Glen,Goggin,Hobbs,Kling,Liu,Madge,Meillerais,Powell,Reynolds,Spacey,Stables,Tatlock,Wheeler,Wishart,Woo

, p. 78 - 93 (2007/10/03)

Database searching and compound screening identified 1-benzyl-3-(3-dimethylaminopropyloxy)-indazole (benzydamine, 3) as a potent activator of the nitric oxide receptor, soluble guanylate cyclase. A comprehensive structure-activity relationship study surrounding 3 clearly showed that the indazole C-3 dimethylaminopropyloxy substituent was critical for enzyme activity. However replacement of the indazole ring of 3 by appropriately substituted pyrazoles maintained enzyme activity. Compounds were evaluated for inhibition of platelet aggregation and showed a general lipophilicity requirement. Aryl-substituted pyrazoles 32, 34, and 43 demonstrated potent activation of soluble guanylate cyclase and potent inhibition of platelet aggregation. Pharmacokinetic studies in rats showed that compound 32 exhibits modest oral bioavailability (12%) Furthermore 32 has an excellent selectivity profile notably showing no significant inhibition of phosphodiesterases or nitric oxide synthases.

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