10400-18-7

Upstream product

• 1068-56-0 isopropylmagnesium iodide 
• 104-88-1 4-chlorobenzaldehyde 
• 78-84-2 isobutyraldehyde 
• 51833-36-4 4-chlorophenylmagnesium chloride 
• 18713-58-1 1-(4-chlorophenyl)-2-methylpropan-1-one 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 1068-55-9 isopropylmagnesium chloride 
• 67-56-1 methanol 
• 3391-10-4 1-(p-chlorophenyl)ethyl alcohol 

Downstream Products

• 19366-15-5 4-chloro-β,β-dimethylstyrene 
• 18713-58-1 1-(4-chlorophenyl)-2-methylpropan-1-one 
• 97619-51-7 Maleinsaeure-mono-<2-methyl-1-(4-chlor-phenyl>-propylester> 
• 96875-25-1 2-Methyl-1-<4-chlor-phenyl>-propyl-hydrogensuccinat 
• 97417-43-1 Glutarsaeure-mono-<2-methyl-1-(4-chlor-phenyl)-propylester> 
• 126275-17-0 3-(4-Chloro-phenyl)-4-methyl-pentanoyl chloride 
• 126275-16-9 3-(4-chlorophenyl)-4-methylpentanoic acid 
• 126275-07-8 3-(4-Chloro-phenyl)-4-methyl-pent-3-enoic acid ethyl ester 
• 126275-08-9 (E)-3-(4-Chloro-phenyl)-4-methyl-pent-2-enoic acid ethyl ester 
• 126275-09-0 3-(4-Chloro-phenyl)-4-methyl-pentanoic acid ethyl ester 
• 126275-06-7 3-(4-Chloro-phenyl)-3-hydroxy-4-methyl-pentanoic acid ethyl ester 
• 74648-80-9 3-(4-Chloro-phenyl)-4-methyl-pentanoic acid cyano-(3-phenoxy-phenyl)-methyl ester 
• 137408-30-1 (S)-2-methyl-1-(4-chlorophenyl)propyl acetate 
• 1396747-54-8 (R)-2-methyl-1-(4-chlorophenyl)propyl acetate 

Relevant academic research and scientific papers

Ruthenium(II)-Catalyzed β-Methylation of Alcohols using Methanol as C1 Source

Selective introduction of methyl branches into the carbon chains of alcohols can be achieved with low loadings of ruthenium precatalyst [RuH(CO)(BH4)(HN(C2H4PPh2)2)] (Ru-MACHO-BH) using methanol both as methylating reagent and as reaction medium. A wide range of structurally divers alcohols was β-methylated with excellent selectivity (>99 %) in fair to high yields (up to 94 %) under standard conditions, and turnover numbers up to 18,000 could be established. The overall reaction rate of the complex catalytic network appears to be governed by interconnection of the individual subcycles through availability of the reactive intermediates. The synthetic procedure opens pathways to important structural motifs following the Green Chemistry principles.

Zinc(II)-catalyzed addition of grignard reagents to ketones

(Figure presented) The addition of organometallic reagents to carbonyl compounds has become a versatile method for synthesizing tertiary and secondary alcohols via carbon-carbon bond formation. However, due to the lack of good nucleophilicity or the presence of strong basicity of organometallic reagents, the efficient synthesis of tertiary alcohols from ketones has been particularly difficult and, thus, limited. We recently developed highly efficient catalytic alkylation and arylation reactions to ketones with Grignard reagents (RMgX: R = alkyl, aryl; X = Cl, Br, I) using ZnCl2, Me3SiCH 2MgCl, and LiCl, which effectively minimize problematic side reactions. In principle, RMgBr and RMgI are less reactive than RMgCl for the addition to carbonyl compounds. Therefore, this novel method with homogeneous catalytic ZnCl2·Me3SiCH2MgCl·LiCl is quite attractive, since RMgBr and RMgI, which are easily prepared and/or commercially available, like RMgCl, can be applied successfully. As well as ketones and aldehydes, aldimines were effectively applied to this catalysis, and the corresponding secondary amines were obtained in high yield. With regard to mechanistic details concerning β-silyl effect and salt effect, in situ-prepared [R(Me3SiCH2)2Zn] -[Li]+[MgX2]m[LiCl]n (X = Cl/Br/I) is speculated to be a key catalytic reagent to promote the reaction effectively. The simplicity of this reliable ZnCl2·Me 3SiCH2MgCl·LiCl system in the addition of Grignard reagents to carbonyl compounds might be attractive for industrial as well as academic applications.

17-Beta hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases

There are disclosed compounds of the formula (I): prodrugs thereof, or pharmaceutically acceptable salts of the compounds or of said prodrugs which are useful as inhibitors of Type 3 17β-Hydroxysteroid Dehydrogenase. Also disclosed are pharmaceutical compositions containing said compounds and their use for the treatment or prevention of androgen dependent diseases.

Methods and compositions for protecting animals and humans against attack and infestation by arthropod and helminth parasites

The present invention relates to methods and compositions for treating animals and humans, and for controlling, preventing and protecting animals and humans from infestation and infection by arthropod and helminth parasites by administering or applying to

1,4-diaryl-2,3-difluoro-2-butene insecticidal and acaricidal agents

Pesticidal 1,4-diaryl-2,3-difluoro-2-butene compounds having the structural formula I and compositions and methods comprising those compounds for the control of insect and acarid pests.

Methods and compositions for protecting animals and humans against attack and infestation by arthropod and helminth parasites

The present invention relates to methods and compositions for treating animals and humans, and for controlling, preventing and protecting animals and humans from infestation and infection by arthropod and helminth parasites by administering or applying to

Preparation of 2,2-diorgano-3-arylpropionic acids and esters thereof

A process for the preparation of 2,2-diorgano-3-arylpropionic acids is disclosed by the carbonylation of corresponding 2,2-diorgano-1-aryl ethanol in the presence of a Lewis acid catalyst. Furthermore, a process for the production of 2,2-diorgano-3-arylpr

1,2-Secopyrethroids: Synthesis of (+/-) α-(RS)-cyano-3-phenoxybenzyl-4-methyl-3-phenyl/p-substituted-phenylpentanoates

A simple, elegant synthesis of (+/-) α-(RS)-cyano-3-phenoxybenzyl-4-methyl-3-phenyl/p-substituted-phenylpentanoates (I,XIV,XXI) has been described.