10403-73-3

Basic information

• Product Name: Benzene, 1,2-bis(phenylmethoxy)-
• CAS NO: 10403-73-3
• Molecular Formula: C20H18O2
• Molecular Weight: 290.362
• Mol File: 10403-73-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzene, 1,2-bis(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,2-bis(phenylmethoxy)-(10403-73-3)
• EPA Substance Registry System: Benzene, 1,2-bis(phenylmethoxy)-(10403-73-3)

Safety Data

• Hazardous Substances Data: 10403-73-3(Hazardous Substances Data)

Usage

General Description

Benzene, 1,2-bis(phenylmethoxy)-, also known as 1,2-bis(phenylmethoxy)benzene or diphenylmethanediol, is a chemical compound with the molecular formula C20H18O2. It is a colorless to light brown liquid with a sweet, floral odor. This chemical is used as a fragrance in perfumes and cosmetics and as a flavoring agent in food products. It is also used in the production of polymers and resins. However, exposure to this compound can be harmful, as it is classified as a potential human carcinogen and may cause skin and eye irritation. Therefore, proper handling and ventilation are necessary when working with this chemical.

Upstream product

• 100-44-7 benzyl chloride 
• 120-80-9 benzene-1,2-diol 
• 635-67-6 dimethyl phthalate 
• 100-39-0 benzyl bromide 
• 153185-80-9 1,2-bis((tert-butyldimethylsilyl)oxy)benzene 
• 64-17-5 ethanol 
• 584-08-7 potassium carbonate 

Downstream Products

• 70051-91-1 2-Acetamido-2-(3.4-dibenzoyloxybenzoyl)-propionsaeureethylester 
• 29484-19-3 2-Acetamido-2-(3.4-dibenzyloxybenzoyl)-propionsaeurebenzylester 
• 103-41-3 (E)-cinnamic acid benzyl ester 
• 1388829-35-3 C₆₁H₅₀O₁₀ 
• 1388829-33-1 (R,E)-1-methoxycarbonyl-2-[3,4-bis(benzyloxy)phenyl]ethyl-3-[7-(benzyloxy)-2-[3,4-bis(benzyloxy)phenyl]-1-benzofuran-4-yl]acrylate 
• 1388829-29-5 (E)-3-(7-(benzyloxy)-2-(3,4-bis(benzyloxy)phenyl)benzo[b]furan-4-yl)acrylic acid 
• 1388829-28-4 C₃₆H₂₈O₅ 
• 1141892-88-7 (((4-ethynyl-1,2-phenylene)bis(oxy))bis(methylene))dibenzene 
• 1141892-87-6 3,4-di(benzyloxy)phenylethynyl(trimethyl)silane 
• 17301-77-8 3,4-Dimethoxy-3',4'-dibenzyloxybiphenyl 
• 32568-24-4 2(e)-<3,4-Dibenzyloxy-phenyl>-3(a)-iod-trans-decalin-2a-isocyanat; (+/-)-<2c-(3,4-Dibenzyloxy-phenyl)-3c-iod-(4ar,8at)-decahydro-(2t)-naphthyl>-isocyanat 

Relevant articles and documents

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PROCESS FOR PRODUCTION OF HYDROXYTYROSOL USING ORGANOMETALLIC COMPOUNDS

Disclosed is a process for the production of a 4-(2-hydroxyalkyl)-1,2-benzenediol, comprising the steps of (a) providing protected 1,2-benzenediol having the 1,2-hydroxyl groups protected, (b) halogenating the protected 1,2-benzenediol to obtain a protected 4-halo-1,2-benzenediol having the 1,2-hydroxyl groups protected, (c) reacting, in the presence of a metal or organometallic compound, the protected 4-halo-1,2-benzenediol to protected 4-(2-hydroxyalkyl)-1,2-benzenediol having the 1,2-hydroxyl groups protected, and (d) deprotecting the protected 4-(2-hydroxyalkyl)-1,2-benzenediol to obtain the 4-(2-hydroxyalkyl)-1,2-benzenediol. Also disclosed is the use of 1,2-benzenediol for the production of hydroxytyrosol.

Synthesis and structure-function analysis of Fe(II)-form-selective antibacterial inhibitors of Escherichia coli methionine aminopeptidase

Methionine aminopeptidase (MetAP) is a promising target for the development of novel antibacterial, antifungal and anticancer therapy. Based on our previous results, catechol derivatives coupled with a thiazole or thiophene moiety showed high potency and selectivity toward the Fe(II)-form of Escherichia coli MetAP, and some of them clearly showed antibacterial activity, indicating that Fe(II) is likely the physiologically relevant metal for MetAP in E. coli and other bacterial cells. To further understand the structure-function relationship of these Fe(II)-form selective MetAP inhibitors, a series of catechol derivatives was designed and synthesized by replacement of the thiazole or thiophene moiety with different five-membered and six-membered heterocycles. Inhibitory activities of these newly synthesized MetAP inhibitors indicate that many five- and six-membered rings can be accommodated by MetAP and potency on the Fe(II)-form can be improved by introducing substitutions on the heterocyles to explore additional interactions with the enzyme. The furan-containing catechols 11-13 showed the highest potency at 1 μM on the Fe(II)-form MetAP, and they were also among the best inhibitors for growth inhibition against E. coli AS19 strain. These findings provide useful information for the design and discovery of more effective MetAP inhibitors for therapeutic applications.