1040373-73-6

Basic information

• Product Name: 2-(4-fluorophenyl)-2-hydroxy-1-methyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide
• Synonyms: 2-(4-fluorophenyl)-2-hydroxy-1-methyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide
• CAS NO: 1040373-73-6
• Molecular Weight: 326.168
• Mol File: 1040373-73-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)-2-hydroxy-1-methyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-2-hydroxy-1-methyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide(1040373-73-6)
• EPA Substance Registry System: 2-(4-fluorophenyl)-2-hydroxy-1-methyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide(1040373-73-6)

Safety Data

• Hazardous Substances Data: 1040373-73-6(Hazardous Substances Data)

Upstream product

• 931-61-3 N-methylpyrimidin-2-amine 
• 403-29-2 2-bromo-4'-fluoroacetophenone 

Downstream Products

• 787586-61-2 2-(4-fluorophenyl)-1-methylimidazo[1,2-a]pyrimidin-1-ium perchlorate 
• 1313605-38-7 N-methyl-5-(4-fluorophenyl)-1H-imidazol-2-amine 

Relevant articles and documents

A divergent synthesis of substituted 2-aminoimidazoles from 2-aminopyrimidines

(Chemical Equation Presented) A new divergent and efficient synthesis of substituted 2-aminoimidazoles 5 and 6 has been developed starting from the readily available 2-aminopyrimidines 1 and α-bromocarbonyl compounds 2, using conventional heating or microwave irradiation. Thus, the cleavage of 1,2,3-substituted imidazo[1,2-a]pyrimidin-1-ium salts 4 with hydrazine or secondary amines led to 1,4,5-trisubstituted 2-aminoimidazoles 5, when the hydrazinolysis of 2-hydroxy-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium salts 3, followed by a novel Dimroth-type rearrangement, resulted in formation of 2-amino-1H-imidazoles 6. The relevant pathway of transformations was identified by characterization of the intermediates.