104072-35-7

Upstream product

• 104072-34-6 2-(3,4-Dimethoxy-phenyl)-2-pent-4-enyl-[1,3]dithiane 
• 50766-67-1 2-(3,4-dimethoxyphenyl)-1,3-dithiane 
• 852878-89-8 pent-4-en-1-yl benzenesulfonate 
• 5162-44-7 1-bromo-4-butene 
• 72862-53-4 N'-[1-(3,4-Dimethoxy-phenyl)-eth-(E)-ylidene]-N,N-dimethyl-hydrazine 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 1119-51-3 bromopentene 

Downstream Products

• 1393749-80-8 1-(3,4-dimethoxyphenyl)-4-hydroxyhex-5-en-1-one 
• 104072-36-8 2-(3,4-Dimethoxy-phenyl)-hepta-1,6-dien-3-ol 

Relevant academic research and scientific papers

Ni-Catalyzed 1,2-Diarylation of Alkenyl Ketones: A Comparative Study of Carbonyl-Directed Reaction Systems

A nickel-catalyzed 1,2-diarylation of alkenyl ketones with aryl iodides and arylboronic esters is reported. Ketones with a variety of substituents serve as effective directing groups, offering high levels of regiocontrol. A representative product is diversified into a wide range of useful products that are not readily accessible via existing 1,2-diarylation reactions. Preliminary mechanistic studies shed light on the binding mode of the substrate, and Hammett analysis reveals the effect of electronic factors on initial rates.

Copper-catalyzed oxaziridine-mediated oxidation of C-H bonds

The highly regio- and chemoselective oxidation of activated C-H bonds has been observed via copper-catalyzed reactions of oxaziridines. The oxidation proceeded with a variety of substrates, primarily comprising allylic and benzylic examples, as well as one example of an otherwise unactivated tertiary C-H bond. The mechanism of the reaction is proposed to involve single-electron transfer to the oxaziridines to generate a copper-bound radical anion, followed by hydrogen atom abstraction and collapse to products, with regeneration of the catalyst by a final single-electron transfer event. The involvement of allylic radical intermediates was supported by a radical-trapping experiment with TEMPO.