104084-48-2Relevant academic research and scientific papers
Directed lithiation of unprotected pyridinecarboxylic acids
Mongin, Florence,Trecourt, Francois,Queguiner, Guy
, p. 5483 - 5486 (2007/10/03)
The lithium salts of 2-, 3- and 4-pyridinecarboxylic acids undergo deprotonation at the position adjacent to the carboxylate group when treated with LTMP in THF at 0 °C, -50 °C and -25 °C, respectively. The lithiation conditions could be extended to chlor
Regioselective synthesis of 1,8-diazaanthracene-9,10-dione by tandem directed ortho-metallation/metal-halogen exchange
Villacampa, Mercedes,De La Cuesta, Elena,Avendano, Carmen
, p. 1259 - 1264 (2007/10/02)
Tandem directed ortho-metallation/metal-halogen exchange reactions between N,N-diethylpyridine-2-carboxamide and 2-bromopyridine-3-carbaldehyde yield 1,8-diazaanthracene-9,10-dione. This compound has been further functionalized to its N-oxide and the corr
APPLICATIONS of ORGANOLITHIUM and RELATED REAGENTS in SYNTHESIS. Part IV. A General Study of the Reaction of N,N-Dialkylpyridinecarboxamides with Lithium Diisopropylamide
Epsztajn, Jan,Brzezinski, Jacek Z.,Jozwiak, Andrzej
, p. 401 - 441 (2007/10/02)
The reactions of the N,N-dialkylpyridinecarboxamides (1), (2) and (3) derived from picolinic, nicotinic and isonicotinic acids with lithium diisopropylamides have been examied.It is shown that in contrast with N,N-diethylpyridinecarboxamides (1a), (2a) an
