10409-20-8

Basic information

• Product Name: 1,4-Naphthalenedione, 2-(4-chlorophenyl)-3-hydroxy-
• CAS NO: 10409-20-8
• Molecular Formula: C16H9ClO3
• Molecular Weight: 284.699
• Mol File: 10409-20-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,4-Naphthalenedione, 2-(4-chlorophenyl)-3-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Naphthalenedione, 2-(4-chlorophenyl)-3-hydroxy-(10409-20-8)
• EPA Substance Registry System: 1,4-Naphthalenedione, 2-(4-chlorophenyl)-3-hydroxy-(10409-20-8)

Safety Data

• Hazardous Substances Data: 10409-20-8(Hazardous Substances Data)

Upstream product

• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 106-47-8 4-chloro-aniline 
• 35135-38-7 2-hydroxy-3-iodonaphthalene-1,4-dione 
• 1679-18-1 4-Chlorophenylboronic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 117560-06-2 3-phenyliodonio-1,2,4-trioxo-1,2,3,4-tetrahydronaphthalenide 
• 130-15-4 [1,4]naphthoquinone 
• 1785-67-7 1,2,4-triacetyloxynaphthalene 

Relevant articles and documents

Pd(II)-Catalyzed Synthesis of Alkylidene Phthalides via a Decarbonylative Annulation Reaction

An unprecedented Pd(II)-catalyzed decarbonylative C-H/C-C activation and annulation reaction, which proceeds via intramolecular cyclization, is reported. This reaction of hydroxynaphthoquinones with disubstituted alkynes provides good yields of substituted alkylidene phthalides, which are the key intermediates for the synthesis of bioactive natural products.

Arylation of lawsone through BF3-mediated coupling of its phenyliodonium ylide with activated arenes and aromatic aldehydes

Phenyliodonium ylide of lawsone, activated by BF3·Et 2O, reacts with electron-rich arenes to afford the corresponding 2-aryl-3-hydroxy-1,4-naphthoquinones, in a coupling reaction without metal catalysts. The same type of products, in greater variety and higher yields, are obtained from the reaction of the BF3·Et2O- activated ylide with aromatic aldehydes in a synthetically and mechanistically interesting deformylation reaction.