10409-56-0

Upstream product

• 814-49-3 diethyl chlorophosphate 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 122-52-1 triethyl phosphite 
• 4206-67-1 iodo(trimethylsilyl)methane 
• 3453-00-7 diethyl benzoylmethylphosphonate 
• 1895-97-2 2-methyl-3-phenylacrylic acid 
• 762-04-9 phosphonic acid diethyl ester 
• 637-50-3 1-phenylpropene 
• 74-88-4 methyl iodide 
• 100-42-5 styrene 
• 673-32-5 1-Phenylprop-1-yne 
• 78-38-6 ethylphosphonic acid diethyl ester 
• 37471-46-8 1-phenyl-1-trimethylsiloxypropene 

Downstream Products

• 93-55-0 1-phenyl-propan-1-one 
• 769-60-8 2-methyl-1-phenylprop-2-en-1-one 

Relevant academic research and scientific papers

Reaction of silyl enol ethers with phosphite using hypervalent iodine compound: A new synthesis of 2-aryl-2-oxoalkylphosphonates

Reaction of phosphite with silyl enol ethers using iodosobenzene/boron trifluoride etherate provides a direct route for the preparation of 2-aryl- 2-oxoalkylphosphonates in good yields.

Synthesis of 1,3-Aminoalcohols and Spirocyclic Azetidines via Tandem Hydroxymethylation and Aminomethylation Reaction of β-Keto Phosphonates with N-Nosyl- O-(2-bromoethyl)hydroxylamine

An unprecedented tandem α-hydroxymethylation and α-aminomethylation reaction of aromatic cyclic β-keto phosphonates with N-nosyl-O-(2-bromoethyl)hydroxylamine in the presence of DBU base has been developed, affording a range of 1,3-aminoalcohols in good y

Copper-Catalyzed Microwave-Expedited Oxyphosphorylation of Alkynes with Diethyl Phosphite and t-Butyl Hydroperoxide Synthesis of Densely Functionalized Phosphonylated Indenones

Treatment of alkynes with diethyl phosphite and t-butyl hydroperoxide in the presence of [Cu(MeCN)4]BF4 under microwave irradiation produced the oxyphosphorylation of the triple bond, giving rise to the corresponding β-ketophosphonates in moderate-to-good yields. When the triple bond was conjugated to a carbonyl group bearing an aromatic ring, it led to the cyclization of the resulting ketone intermediate, producing eventually different phosphonylated indenones.

Manganese-catalyzed oxophosphorylation reaction of carbon–carbon double bonds using molecular oxygen in air

A novel aerobic manganese-catalyzed oxophosphorylation reaction of carbon–carbon double bonds of styrene derivatives and vinyl ethers using diethyl H-phosphonates was developed. This direct transformation of alkenes to β-ketophosphonate readily proceeded at room temperature via the direct incorporation of molecular oxygen present in air (open flask).

Preparation method for synthesizing beta-carbonyl phosphonate derivatives via olefin

The invention discloses a method for synthesizing beta-carbonyl phosphonate derivatives via olefin and belongs to the field of organic chemistry. In the method, olefin (or olefin acid) and H-phosphite are used as raw materials, CuSO4.5H2O is used as a catalyst, and beta-carbonyl phosphonate derivatives are synthesized by heating reaction. The method is cheap and readily available in raw materials, simple in operation, mild in reaction condition and high in synthetic yield, and is suitable for industrialized production. The derivatives are often used as intermediates for synthesizing alpha, beta-unsaturated carbonyl compounds, and the derivatives also have wide bioactivity and significant metal compounding capability and play an irreplaceable role in medicinal chemistry, biological chemistry and inorganic chemistry.

Cu(i)/Fe(III)-Catalyzed C-P cross-coupling of styrenes with H-phosphine oxides: A facile and selective synthesis of alkenylphosphine oxides and β-ketophosphonates

Cu(i)/Fe(iii)-Catalyzed phosphorylation and oxyphosphorylation of styrenes with H-phosphonates which can be controlled by varying the reaction temperature are developed. This study offers a new and expedient strategy for the synthesis of useful alkenylphosphine oxides and β-ketophosphonates in satisfactory yields. Moreover, the transformation is proposed to proceed via a radical process and exhibits a broad substrate scope and good functional group tolerance.

Acetonitrile-dependent oxyphosphorylation: A mild one-pot synthesis of β-ketophosphonates from alkenyl acids or alkenes

An efficient one-pot synthesis of β-ketophosphonates has been developed, via the reaction of α,β-alkenyl carboxylic acids or alkenes with H-phosphonates and air oxygen, catalyzed by CuSO4·5H2O in CH3CN. CH3CN plays a decisive role, probably by forming an active oxygen complex [(MeCN)nCuII-O-O·].

Synthesis of α-trifluoromethyl-β-keto phosphonates by electrophilic trifluoromethylation with Togni reagent

A new synthetic method of trifluoromethylated phosphonates was developed via electrophilic trifluoromethylation with Togni reagent. A variety of β-keto phosphonates were converted into the corresponding α-trifluoromethyl-β-keto phosphonates in moderate to good yields. This protocol could also be extended to other fluoroalkylation reactions, such as pentafluoroethylation.

A one-pot strategy to synthesize β-ketophosphonates: Silver/copper catalyzed direct oxyphosphorylation of alkynes with H-phosphonates and oxygen in the air

A highly efficient one-pot strategy has been developed for the synthesis of β-ketophosphonates directly from alkynes and dialkyl H-phosphonates in the presence of widely available AgNO3/CuSO4 and K2S2O8 at room temperature under open-air conditions.

β-Ketophosphonate formation via aerobic oxyphosphorylation of alkynes or alkynyl carboxylic acids with H-phosphonates

A synergistic Cu/Fe-catalyzed aerobic oxyphosphorylation of alkynes or alkynyl carboxylic acids with H-phosphonate is disclosed. The useful β-ketophosphonate products were obtained in good yields under oxygen atmosphere in a novel way. This reaction exhibits a wide substrate scope, and the mechanistic experiments indicate that a radical mechanism forms both C-P and C=O bonds simultaneously. This mechanism contrasts existing aerobic difunctionalization of alkynes.