1040918-08-8Relevant academic research and scientific papers
Synthesis of the 5′-Fluoro-2′β-methyl analogues of neplanocin
Kumamoto, Hiroki,Kobayashi, Marina,Kato, Nobuyuki,Balzarini, Jan,Tanaka, Hiromichi
, p. 2685 - 2691 (2011/06/28)
Synthesis of the 5′-fluoro-2′-β-methyl analogues of neplanocin was carried out. Key intermediate cyclopentenone 19 was prepared from methyl α-D-mannopyranoside by a new approach consisting of ring-closing metathesis, stereoselective introduction of the 2′
Synthesis of 2′-β-C-methyl-neplanocin derivatives as anti-HCV agents
Liao, Xibin,Butora, Gabor,Olsen, David B.,Carroll, Steven S.,McMasters, Daniel R.,Leone, Joseph F.,Stahlhut, Mark,Doss, George A.,Yang, Lihu,MacCoss, Malcolm
, p. 4149 - 4152 (2008/09/20)
The synthesis of 2′-β-C-methyl-neplanocin derivatives is described. The key intermediate cyclopentenyl alcohol 12 is prepared from sugar 5 in 12 steps. Coupling of 12 with appropriately protected purine, 7-deaza pyrimidine, uracil and pyrimidine bases via
