1040922-30-2Relevant academic research and scientific papers
Synthesis, enzyme assays and molecular docking studies of fluorinated bioisosteres of santacruzamate a as potential HDAC tracers
Ahamed, Muneer,Vermeulen, Koen,Schnekenburger, Michael,Moltzau, Lise Román,Levy, Finn Olav,Marton, János,Froeyen, Mathy,Olberg, Dag Erlend,Diederich, Marc,Bormans, Guy
, p. 787 - 797 (2017/08/07)
Background: Histone deacetylases (HDACs) emerged as important epigenetic regulators of gene expression. Method: In order to identify potential positron emission tomography (PET) tracers for imaging HDACs, we evaluated in vitro and in cellulo activities of
Nickel-mediated oxidative fluorination for PET with aqueous [ 18F] fluoride
Lee, Eunsung,Hooker, Jacob M.,Ritter, Tobias
, p. 17456 - 17458 (2013/01/15)
A one-step oxidative fluorination for carbon-fluorine bond formation from well-defined nickel complexes with oxidant and aqueous fluoride is presented, which enables a straightforward and practical 18F late-stage fluorination of complex small molecules with potential for PET imaging.
Mechanism of C-F reductive elimination from palladium(IV) fluorides
Furuya, Takeru,Benitez, Diego,Tkatchouk, Ekaterina,Strom, Alexandra E.,Tang, Pingping,Goddard III, William A.,Ritter, Tobias
supporting information; experimental part, p. 3793 - 3807 (2010/05/15)
The first systematic mechanism study of C-F reductive elimination from a transition metal complex is described. C-F bond formation from three different Pd(IV) fluoride complexes was mechanistically evaluated. The experimental data suggest that reductive elimination occurs from cationic Pd(IV) fluoride complexes via a dissociative mechanism. The ancillary pyridyl-sulfonamide ligand plays a crucial role for C-F reductive elimination, likely due to a K 3 coordination mode, in which an oxygen atom of the sulfonyl group coordinates to Pd. The pyridyl-sulfonamide can support Pd(IV) and has the appropriate geometry and electronic structure to induce reductive elimination.
SYSTEM FOR FLUORINATING ORGANIC COMPOUNDS
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Page/Page column 237-238, (2009/10/09)
Described herein are fluorinated organic compounds and methods of making fluorinated organic compounds, for example, using palladium complexes. Also described herein are compositions and kits containing compounds and palladium complexes described herein.
Carbon-fluorine reductive elimination from a high-valent palladium fluoride
Furuya, Takeru,Ritter, Tobias
supporting information; experimental part, p. 10060 - 10061 (2009/02/03)
We have observed two high-valent arylpalladiumfluoride complexes that afford carbon-fluorine bond formation upon thermolysis. Copyright
