1041013-49-3Relevant academic research and scientific papers
A novel method to enable SNAr reaction of aminopyrrolopyrazoles
Guo, Chuangxing,Dong, Liming,Marakovits, Joseph,Kephart, Susan
, p. 1692 - 1696 (2011)
Here we report mild, environmentally-friendly reaction conditions which enable the addition-elimination SNAr reaction between weakly reactive substrates - an aminopyrrolopyrazole template and several substituted pyrimidines. The method was developed during our efforts to synthesize a series of novel P21-activated kinase (PAK) inhibitors.
CARBONYLAMINO PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS
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Page/Page column 66, (2009/12/28)
Carbonylamino Pyrrolopyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.
