A novel method to enable SNAr reaction of aminopyrrolopyrazoles

DOI: 10.1016/j.tetlet.2011.01.148

Source and publish data:

Tetrahedron Letters p. 1692 - 1696 (2011)

Update date:2022-07-29

Topics:

Authors:

Guo, Chuangxing

Dong, Liming

Marakovits, Joseph

Kephart, Susan

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/j.tetlet.2011.01.148

Here we report mild, environmentally-friendly reaction conditions which enable the addition-elimination S_NAr reaction between weakly reactive substrates - an aminopyrrolopyrazole template and several substituted pyrimidines. The method was developed during our efforts to synthesize a series of novel P21-activated kinase (PAK) inhibitors.

Full text of DOI:10.1016/j.tetlet.2011.01.148

Products guided by the article

Product name:3-(acetylamino)-N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1h)-carboxamide

Cas No:1041013-49-3

R&D Labs maybe for 1041013-49-3

Chinapeptides Co,. Ltd

Contact:+86-021-50792271

Address:Building 24A, 300 Chuantu Road, Chuansha, Pudong new area, Shanghai, China, 201202
Guangzhou Flower's Song Fine Chemical CO,. Ltd

Contact:+86-20-87475199

Address:No.12, Fenghuang 3 Road, Jiulong Industrial Park, Luogang District, Guangzhou. China
Frapp's Chemical (NFTZ) Co.,Ltd

Contact:+86-576-86137892

Address:General Chamber of Commercial Building, 159 Wanchang Middle Road, Wenling, Zhejiang, China
Baoding City Light Industry And Textiles Imp.& Exp. Corp. Chemical Department.

Contact:86-312-3262436

Address:NO.658 CHAOYANG SOUTH STREET,BAODING CITY HEBEI CHINA
Hangzhou innopharma technology Co,.Ltd.(expird)

Contact:+86-13388601988

Address:Room845,lixin building, moganshan road, hangzhou, china

Relevant to this article

Microwave-assisted three-component Knoevenagel-nucleophilic aromatic substitution reactions

Doi:10.1016/j.tetlet.2008.05.122
(2008)
Clarification of the oxidation state of cobalt corroles in heterogeneous and homogeneous catalytic reduction of dioxygen

Doi:10.1021/ic800458s
(2008)
Strong interactions in covalently stacked trimeric porphyrins

Doi:10.1039/c39860000665
(1986)
Chiral 2-Thioxotetrahydro-1,3-O,N-heterocycles from Carbohydrates. 2. Stereocontrolled Synthesis of Oxazolidine Pseudo-C-nucleosides and Bicyclic Oxazine-2-thiones

Doi:10.1021/jo00071a032
(1993)
Partial hydrogenation of alkynes to cis-olefins by using a novel Pd ⁰-polyethyleneimine catalyst

Doi:10.1002/chem.200800535
(2008)
Synthesis, X-ray structure, and binding properties of a new fluorescent molecular clip derived from diethoxycarbonyl glycoluril

Doi:10.1139/V08-058
(2008)

Article Doi