104143-50-2

Upstream product

• 104143-48-8 2,2-dimethyl 5-nitro 5-p-nitrobenzyl 1,3-dioxane 
• 100-14-1 4-nitrobenzyl chloride 
• 104143-49-9 2,2-dimethyl 5-p-nitrobenzylidene 1,3-dioxane 

Downstream Products

• 477337-69-2 1-(3-chloro-2-chloromethylprop-1-enyl)-4-nitrobenzene 
• 635283-73-7 C₂₄H₁₇N₃O₁₂ 
• 1346258-39-6 C₁₉H₃₁N₃O₆P₂ 
• 1346258-37-4 C₂₁H₃₃Cl₂N₃O₆P₂ 
• 635283-75-9 C₃₂H₃₃N₃O₁₀ 

Relevant academic research and scientific papers

BISPHOSPHONAMIDATE PRODRUGS AND USES THEREOF

Bisphosphonamidate prodrugs of therapeutic bisphosphonate compounds and uses thereof to treat diseases are described.

Preparation and antiparasitic activity of new imidazoles bearing dioxane or hexahydropyrimidine moiety

5-Nitro-1,3-dioxane and 5-nitrohexahydropyrimidine salts are found to be suitable nucleophiles for S(RN)1 reactions. From C-alkylation products, base-promoted nitrous acid elimination and acid-catalyzed cleavage of the resulting acetals afford new compounds. Only the imidazole derivatives exhibit significant amoebicide and trichomonacide activities. Structure-activity relationships are discussed.

REACTIONS SRN1 EN SERIE HETEROCYCLIQUE: IV: REACTIVITE DES SELS DU DIMETHYL-2,2 NITRO-5 DIOXANNE-1,3

2-Alkyl 2-nitro 1,3-propanediol, 2-alkylidene 1,3-propanediol and 2-dialkylidene 1,3-propanediol are prepared via SRN1 reactions with salts of 2,2-dimethyl 5-nitro 1,3-dioxane and acid-catalyzed cleavage of the resulting acetals.