104144-06-1

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Benzenesulfonamide, N,N-di-3-buten-1-yl-4-methylis used as a raw material for the synthesis of various pharmaceuticals and agrochemicals, leveraging its potential biological activity to contribute to the development of new drugs and pesticides.
Used in Organic Synthesis:
Benzenesulfonamide, N,N-di-3-buten-1-yl-4-methylserves as a building block in organic synthesis, enabling the preparation of diverse organic compounds that can be applied across multiple industries, including the chemical and materials science sectors.
Used in Medicinal Chemistry and Drug Discovery:
Benzenesulfonamide, N,N-di-3-buten-1-yl-4-methylis utilized in the field of medicinal chemistry and drug discovery, where its unique structure and properties are studied for potential applications in the creation of novel therapeutic agents.

Upstream product

• 5162-44-7 1-bromo-4-butene 
• 70-55-3 toluene-4-sulfonamide 
• 63-74-1 sulfanilamide 

Downstream Products

• 57502-57-5 (Z)-1-tosyl-2,3,6,7-tetrahydro-1H-azepine 
• 57186-75-1 1-tosyl-1,2,5,6-tetrahydropyridine 
• 74-85-1 ethene 
• 106275-30-3 4-methyl-N,N-bis-(3-oxo-propyl)-benzenesulfonamide 

Relevant academic research and scientific papers

IBX as a catalyst for dehydration of hydroperoxides: Green entry to α,β-unsaturated ketones: Via oxygenative allylic transposition

A catalytic transformation of allylic hydroperoxides into α,β-unsaturated carbonyl compounds using IBX as a dehydration catalyst is described. The combination of a singlet oxygen ene reaction and the IBX-catalyzed dehydration provides α,β-unsaturated carbonyl compounds from alkenes via oxygenative allylic transposition with H2O as the only byproduct.

Tandem ring-closing metathesis/transfer hydrogenation: Practical chemoselective hydrogenation of alkenes

An operationally simple chemoselective transfer hydrogenation of alkenes using ruthenium metathesis catalysts is presented. Of great practicality, the transfer hydrogenation reagents can be added directly to a metathesis reaction and effect hydrogenation of the product alkene in a single pot at ambient temperature without the need to seal the vessel to prevent hydrogen gas escape. The reduction is applicable to a range of alkenes and can be performed in the presence of aryl halides and benzyl groups, a notable weakness of Pd-catalyzed hydrogenations. Scope and mechanistic considerations are presented.

Low catalyst loading in ring-closing metathesis reactions

An efficient procedure is described for ring-closing metathesis reactions. A conversion of 95 % for diethyl diallylmalonate in dilute solution could be achieved within a few minutes, reaching TOF=4173min-1, with very low loading of commercially available Ru catalysts that contained unsaturated NHC ligands. In general, only 50 to 250ppm of the catalyst is required to achieve near-quantitative conversion into a broad variety of 5-16-membered heterocyclic compounds. The practicality of this procedure was illustrated in the synthesis of 5-8-membered N-tert-butoxycarbonyl (N-Boc)- and N-para-toluenesulfonyl (N-Ts)-protected cyclic amines and 9-16-membered lactones. The synthesis of macrocyclic proline-based lactams required slightly higher catalyst loadings. Along with monocyclic products, oligomeric byproducts, mostly cyclodimers, were isolated and characterized. Getting some closure: An efficient procedure is described for ring-closing metathesis reactions in which only 50 to 250ppm of catalyst is required to effect almost-quantitative conversion into a broad range of 5-16-membered heterocyclic compounds. The practicality of this procedure was illustrated in the synthesis of 5-8-membered N-protected cyclic amines, 9-16-membered lactones, and 11-16-membered proline-based lactams. Copyright

N-heterocyclic carbene and phosphine ruthenium indenylidene precatalysts: A comparative study in olefin metathesis

Kinetic studies on ring-closing metathesis of unhindered and hindered substrates using phosphine and N-heterocyclic carbene (NHC)-containing ruthenium-indenylidene complexes (first and second generation precatalysts, respectively) have been carried out. T

Synthesis of N-heterocyclic diols by diastereoselective pinacol coupling reactions

A series of 5-8 membered N-heterocyclic diols have been prepared from acyclic dicarbonyls via diastereoselective pinacol reactions whereby cis- or trans-diol stereoselectivity is controlled by the choice of low-valent metal reagent used.

Utilization of Phenylthio Substituted Amines for the Synthesis of Pyrrolidines

α-Phenylthio substituted amines have been found to be convenient reagents for the preparation of the pyrrolidine ring.Benzylamine (2) undergoes 1,3-dipolar cycloaddition with several dipolarophiles in the presence of silver fluoride.The reaction is believed to proceed via the intermediacy of an azomethine ylide.Treatment of α-(phenylthio)cyanoamines 10 and 17 with strong base results in the loss of the phenylthio group, and formation of substituted trans-piperazines 21, 22 in the case of 17.The mechanism of the reaction involves dimerization of the initially formed cyano substituted azomethine ylide intermediate, which behaves as a captodative diradical.Finally, the reaction of several alkenylamines with tributyltin hydride was studied as a method for generating the pyrrolidine ring via a radical cyclization reaction.