104145-71-3

Upstream product

• 18910-10-6 α-bromo-β-(2-nitrophenyl)propionic acid 
• 861329-33-1 2-hydroxy-3-(2-nitro-phenyl)-propionic acid amide 
• 5461-32-5 o-nitrophenylpyruvic acid 
• 112-30-1 1-Decanol 
• 861356-74-3 bromo-(2-nitro-benzyl)-malonic acid 
• 683215-25-0 (2-nitro-benzyl)-malonic acid 
• 2001-32-3 3-(2-nitrophenyl)propionic acid 
• 59803-35-9 (2-nitro-benzyl)-malonic acid diethyl ester 
• 552-89-6 2-nitro-benzaldehyde 
• 98293-46-0 2-methyl-4-(2-nitrobezylidene)-4,5-dihydrooxazol-5-one 

Downstream Products

• 104145-72-4 (-)-α-Chloro-2-nitrobenzenepropanoic acid, 2,6-dimethylpiperidine salt 
• 93424-78-3 α-chloro-β-(o-nitrophenyl)propionic acid 
• 88-72-2 1-methyl-2-nitrobenzene 

Relevant academic research and scientific papers

COMPOUNDS, COMPOSITIONS AND METHODS

Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

Deracemisation of aryl substituted α-hydroxy esters using Candida parapsilosis ATCC 7330: Effect of substrate structure and mechanism

Candida parapsilosis ATCC 7330 was found to be an efficient biocatalyst for the deracemisation of aryl α-hydroxy esters (65-85% yield and 90-99% ee). A variety of aryl and aryl substituted α-hydroxy esters were synthesized to reflect steric and electronic effects on biocatalytic deracemisation. The mechanism of this biocatalytic deracemisation was found to be stereoinversion.

Process for preparing indoline-2-carboxylic acids via alpha-hydroxy-2-nitrobenzenepropanoic acid

Disclosed herein is a process for obtaining indoline-2-carboxylic acid (or derivatives thereof) comprising the following steps: (a) reducing α-oxo-2-nitrobenzenepropanoic acid to α-hydroxy-2-nitrobenzenepropanoic acid, (b) replacing the hydroxyl group of the latter with a chlorine atom utilizing a selected Vilsmeier chlorinating reagent at temperatures of at least 20° C., (c) reducing the nitro group of the resulting α-chloro-2-nitrobenzenepropanoic acid to obtain α-chloro-2-aminobenzenepropanoic acid, and (d) cyclizing the latter in aqueous base to form the desired indoline-2-carboxylic acid. Alternately, steps (c) and (d) may be combined in a one pot step by using, for example, a Raney nickel-hydrazine reducing medium.