59803-35-9

Usage

InChI:InChI=1/C14H17NO6/c1-3-20-13(16)11(14(17)21-4-2)9-10-7-5-6-8-12(10)15(18)19/h5-8,11H,3-4,9H2,1-2H3

Upstream product

• 17455-13-9 18-crown-6 ether 
• 612-23-7 2-nitrobenzyl chloride 
• 105-53-3 diethyl malonate 
• 17422-56-9 diethyl 2-(2-nitrobenzylidene)malonate 
• 64-17-5 ethanol 
• 683215-25-0 (2-nitro-benzyl)-malonic acid 
• 3958-60-9 2-nitrophenylmethyl bromide 

Downstream Products

• 2001-32-3 3-(2-nitrophenyl)propionic acid 
• 1211547-70-4 C₂₄H₃₇NO₇Si 
• 85397-21-3 3-(2-nitro-phenyl)-propionyl chloride 
• 24623-25-4 4-nitro-2,3-dihydro-1H-inden-1-one 
• 612-41-9 2-nitrocinnamic acid 
• 861356-74-3 bromo-(2-nitro-benzyl)-malonic acid 
• 104145-71-3 2-hydroxy-3-(2-nitro-phenyl)-propionic acid 
• 18910-10-6 α-bromo-β-(2-nitrophenyl)propionic acid 
• 88-72-2 1-methyl-2-nitrobenzene 
• 683215-25-0 (2-nitro-benzyl)-malonic acid 

Relevant academic research and scientific papers

NOVEL MALONIC ACID SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

The present invention provides a novel compound having an agonist action at AT2 receptor and expected as a pharmaceutical product, and also provides a method of treating or preventing various diseases. The novel sulfonyl malonamide derivative,

SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted aromatic carboxamide and urea derivatives, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions (formula (I)).

Modified pyrimidine glucocorticoid receptor modulators

The present invention provides a novel class of modified pyrimidine compounds and compositions and methods of using the compounds as glucocorticoid receptor modulators.

TETRAHYDRO-NAPHTHALENE AND UREA DERIVATIVES

This invention relates to a hydroxy-tetrahydro-naphthalene or an urea derivative formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations, wherein A represents formula (II) or (III) wherein # represents the connection position to the molecule and Q1a, Q2a, Q3a and Q4a are defined, and E represents formula (IV) or (V) wherein # represents the connection position to the molecule and Q1b, Q2b, Q3b, Q4b, Q5b, R1b, na, ma, Xa and Ra are defined.

TETRAHYDRO-NAPHTHALENE AND UREA DERIVATIVES

This invention relates to tetrahydro-naphthalene and urea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-naphthalene and urea derivatives of the present invention have vanilloid receptor (VR1) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor oeractivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD). BHC 03 2 001-Foreign-Countries - 66 - BHC 03 2 001-Foreign-Countries - 65 -

4-Heterocyclic-substituted-2-indanyl alcohols and insecticidal ester derivatives

Disclosed are novel compounds of the formula STR1 wherein R1 is a heterocyclic radical selected from furanyl, thienyl, pyridyl, pyrimidyl, oxazolyl, pyrrolyl, isoxazolyl, thiazolyl, and isothiazolyl, and R2 is hydrogen, a tetramethylcyclopropanecarbonyl group, a 1-(substituted-phenyl)-2-methylpropyl-1-carbonyl group, a 1-(4-ethoxyphenyl)-2,2-dichlorocyclopropanecarbonyl group, or a substituted-vinylcyclopropanecarbonyl group. The compounds wherein R2 is other than hydrogen are insecticides.

4-Heterocyclic-substituted-2-indanyl alcohols and insecticidal ester derivatives

Disclosed are novel compounds of the formula STR1 wherein R1 is a heterocyclic radical selected from furanyl, thienyl, pyridyl, pyrimidyl, oxazolyl, pyrrolyl, isoxazolyl, thiazolyl, and isothiazolyl, and R2 is hydrogen, a tetramethylcyclopropanecarbonyl group, a 1-(substituted-phenyl)-2-methylpropyl-1-carbonyl group, a 1-(4-ethoxyphenyl)-2,2-dichlorocyclopropanecarbonyl group, or a substituted-vinylcyclopropanecarbonyl group. The compounds wherein R2 is other than hydrogen are insecticides.

4-Heterocyclic-substituted-2-indanyl alcohols and insecticidal ester derivatives

Disclosed are novel compounds of the formula STR1 wherein R1 is a heterocyclic radical selected from furanyl, thienyl, pyridyl, pyrimidyl, oxazolyl, pyrrolyl, isoxazolyl, thiazolyl, and isothiazolyl, and R2 is hydrogen, a tetramethylcylopropanecarbonyl group, a 1-(substituted-phenyl)-2-methylpropyl-1-carbonyl group, a 1-(4-ethoxyphenyl)-2-dichlorocyclopropanecarbonyl group, or a substituted-vinyl-cyclopropanecarbonyl group. The compounds wherein R2 is other than hydrogen are insecticides.