1041850-97-8Relevant articles and documents
Design, synthesis, and biological evaluation of novel tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: Focus on optimized interactions with the enzyme's surface-exposed front region
Laufer, Stefan A.,Hauser, Dominik R. J.,Domeyer, David M.,Kinkel, Katrin,Liedtke, Andy J.
supporting information; experimental part, p. 4122 - 4149 (2009/05/30)
The synthesis, biological testing, and SAR of novel 2,4,5- and 1,2,4,5-substituted 2-thioimidazoles are described. Amino, oxy, or thioxy substituents at the 2-position of the pyridinyl moiety were evaluated for their contributions to inhibitor potency and