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260065-86-9

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260065-86-9 Usage

General Description

(1R,2S)-2-aminocyclohexanol is a chemical compound with the molecular formula C6H13NO. It is a chiral molecule, meaning it has two enantiomers that are mirror images of each other. (1R,2S)-2-aminocyclohexanol is composed of a cyclohexane ring with an amino group and a hydroxyl group attached to it. It can be used as a chiral auxiliary in asymmetric synthesis, as a reagent in organic chemistry reactions, and as a building block in the synthesis of pharmaceuticals and other fine chemicals. The two enantiomers of (1R,2S)-2-aminocyclohexanol have different pharmacological properties and can exhibit different biological activities, making them important in drug development and research.

Check Digit Verification of cas no

The CAS Registry Mumber 260065-86-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,0,0,6 and 5 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 260065-86:
(8*2)+(7*6)+(6*0)+(5*0)+(4*6)+(3*5)+(2*8)+(1*6)=119
119 % 10 = 9
So 260065-86-9 is a valid CAS Registry Number.

260065-86-9Relevant articles and documents

Helix-forming propensity of aliphatic urea oligomers incorporating noncanonical residue substitution patterns

Pendem, Nagendar,Douat, Celine,Claudon, Paul,Laguerre, Michel,Castano, Sabine,Desbat, Bernard,Cavagnat, Dominique,Ennifar, Eric,Kauffmann, Brice,Guichard, Gilles

supporting information, p. 4884 - 4892 (2013/05/09)

Aliphatic N,N′-linked oligoureas are peptidomimetic foldamers that adopt a well-defined helical secondary structure stabilized by a collection of remote three-center H-bonds closing 12- and 14-membered pseudorings. Delineating the rules that govern helix formation depending on the nature of constituent units is of practical utility if one aims to utilize this helical fold to place side chains in a given arrangement and elaborate functional helices. In this work, we tested whether the helix geometry is compatible with alternative substitution patterns. The central -NH-CH(R)-CH2-NH-CO- residue in a model oligourea pentamer sequence was replaced by guest units bearing various substitution patterns [e.g., -NH-CH2-CH2-NH-CO-, -NH-CH2-CH(R)-NH-CO-, and -NH-CH(R1)-CH(R 2)-NH-CO-], levels of preorganization (cyclic vs acyclic residues), and stereochemistries, and the helix formation was systematically assessed. The extent of helix perturbation or stabilization was primarily monitored in solution by Fourier transform IR, NMR, and electronic circular dichroism spectroscopies. Our results indicate that although three new substitution patterns were accommodated in the 2.5-helix, the helical urea backbone in short oligomers is particularly sensitive to variations in the residue substitution pattern (position and stereochemistry). For example, the trans-1,2- diaminocyclohexane unit was experimentally found to break the helix nucleation, but the corresponding cis unit did not. Theoretical calculations helped to rationalize these results. The conformational preferences in this series of oligoureas were also studied at high resolution by X-ray structure analyses of a representative set of modified oligomers.

Use of enantiomerically pure 7-azabicyclo[2.2.1]heptan-2-ol as a chiral template for the synthesis of aminocyclitols

Pandey, Ganesh,Tiwari, Keshri Nath,Puranik

supporting information; scheme or table, p. 3611 - 3614 (2009/05/07)

(Chemical Equation Presented) Using enantiopure 7-azabicyclo[2.2.1]heptane- 2-ol, the synthesis of cis- as well as trans-2-aminocyclohexanols, dihydroconduramine E-1, and ent-conduramine F-1 has been described.

Kinetic resolution of amino alcohol derivatives with a chiral nucleophilic catalyst: Access to enantiopure cyclic cis-amino alcohols

Kawabata,Yamamoto,Momose,Yoshida,Nagaoka,Fuji

, p. 2700 - 2701 (2007/10/03)

Acylative kinetic resolution of racemic cyclic cis-amino alcohol derivatives with a chiral nucleophilic catalyst proceeds enantioselectively (s = 10-21) at ambient temperature to give enantiopure recovered materials, and the % conversion of the acylation can be readily controlled by the amount of acid anhydride.

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