1041853-11-5

Basic information

• Product Name: ethyl 4-chloro-6,7-dimethoxycinnoline-3-carboxylatre
• Synonyms: ethyl 4-chloro-6,7-dimethoxycinnoline-3-carboxylatre
• CAS NO: 1041853-11-5
• Molecular Weight: 296.71
• Mol File: 1041853-11-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 437.7±55.0 °C(Predicted)
• Density: 1.322±0.06 g/cm3(Predicted)
• CAS DataBase Reference: ethyl 4-chloro-6,7-dimethoxycinnoline-3-carboxylatre(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-chloro-6,7-dimethoxycinnoline-3-carboxylatre(1041853-11-5)
• EPA Substance Registry System: ethyl 4-chloro-6,7-dimethoxycinnoline-3-carboxylatre(1041853-11-5)

Safety Data

• Hazardous Substances Data: 1041853-11-5(Hazardous Substances Data)

Upstream product

• 1041853-04-6 1-(4,5-dimethoxy-2-((E)-pyrrolidin-1-yldiazenyl)phenyl)ethanone 
• 4101-30-8 2-amino-4,5-dimethoxyacetophenone 
• 1284175-28-5 C₁₄H₁₉N₃O₃ 
• 1041853-08-0 ethyl 6,7-dimethoxy-4-oxo-1,4-dihydrocinnoline-3-carboxylatre 

Downstream Products

• 1041853-30-8 ethyl 4-[(2,4-difluorophenyl)amino]-6,7-dimethoxycinnoline-3-carboxylate 
• 1041852-34-9 4-[(2,4-difluorophenyl)amino]-6,7-dimethoxycinnoline-3-carboxamide 
• 1041852-36-1 4-[(2-fluoro-4-methylphenyl)amino]-6,7-dimethoxycinnoline-3-carboxamide 
• 1041852-40-7 4-[(2-fluoro-5-methylphenyl)amino]-6,7-dimethoxycinnoline-3-carboxamide 
• 1041853-32-0 ethyl 4-[(2-fluoro-4-methylphenyl)amino]-6,7-dimethoxycinnoline-3-carboxylate 
• 1041853-34-2 ethyl 4-[(2-fluoro-5-methylphenyl)amino]-6,7-dimethoxycinnoline-3-carboxylate 
• 1041853-33-1 ethyl 4-[(3-chloro-2-fluorophenyl)amino]-6,7-dimethoxycinnoline-3-carboxylate 
• 1041853-35-3 ethyl 4-[(2,3-dichlorophenyl)amino]-6,7-dimethoxycinnoline-3-carboxylate 
• 1041852-42-9 4-[(2,3-dichlorophenyl)amino]-6,7-dimethoxycinnoline-3-carboxamide 

Relevant articles and documents

3-Amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor

3-Amido-4-anilinocinnolines have been identified as potent and highly selective inhibitors of CSF-1R. The synthesis and SAR of these compounds is reported, along with some physical property, pharmacokinetic and kinase selectivity data.

3 - CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER

The invention relates to chemical compounds of formula (I): Formula (I), or pharmaceutically acceptable salts thereof which possess CSF 1R kinase inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti cancer effect in a warm blooded animal such as man.