10419-72-4

Upstream product

• 64-18-6 formic acid 
• 2935-35-5 (S)-2-phenylglycine 
• 875-74-1 D-α-phenylglycine 

Downstream Products

• 84773-28-4 (R)-2-(methylamino)-2-phenylethanol 
• 84694-29-1 2-phenyl>-3-methyl-4(R)-phenyloxazolidine 
• 1420293-69-1 C₉H₈NO₃^(1-)*C₁₆H₃₆N⁽¹⁺⁾ 
• 1258863-72-7 C₁₈H₂₀N₂O₂Se 
• 1258863-73-8 C₁₈H₂₀N₂O₂Se 
• 1258863-48-7 C₁₀H₉NO₂Se 
• 1112970-98-5 C₁₀H₉NO₂ 
• 1112971-05-7 N-formyl-L-phenylalanine methyl ester 
• 136329-39-0 (R)-N-methyl-1-phenyl-2-(pyrrolidin-1-yl)ethanamine 
• 116508-51-1 (1S)-N-methyl-1-phenyl-2-(pyrrolidin-1-yl)ethanamine 
• 143394-39-2 (S)-(+)-2-(N-methylamino)-2-phenylethanol 

Relevant academic research and scientific papers

PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS

The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.

Synthesis of chiral pentacyclo-undecane ligands and their use in the enantioselective alkylation of benzaldehyde with diethylzinc

The synthesis of a new class chiral cage annulated bidentate ligands is reported. The ability of the chiral amino alcohols to catalyse the enantioselective addition of diethyl zinc to benzaldehyde was investigated. The cage annulated amino alcohols have C1 symmetry and showed poor to good enantioselectivity with high chemical yields. The system could be utilised as a versatile probe into the reaction mechanism. The synthesis of a new class of chiral pentacycloundecane cage annulated bidentate ligands is reported. This class of ligands can be used in many reactions that are catalysed by amino alcohol ligands. The ability of the chiral ligands to asymmetrically catalyse the reaction between diethylzinc and benzaldehyde was investigated. The cage annulated bidentate ligands have C1 symmetry and showed poor to good enantioselectivity with high yields compared to previous systems reported using other amino alcohol ligands. An important conclusion from the results is that both ligands should be involved in the mechanism as the bidentate ligands gives much improved enantioselectivity when compared with a single chiral source molecule. This system could be utilised as a versatile probe for examining the reaction mechanism.

New Symmetrical Chiral Dibenzyl- and Diphenyl-Substituted Diamido-, Dithionoamido-, Diaza-, and Azapyridino-18-crown-6 Ligands

Eleven new chiral macrocycles (1-11, see Figure 1) of the pyridino-18-crown-6 type have been prepared.Nine diazapyridino-crown ligands contain two amide (1, R = benzyl; 4, R = phenyl), two N-methylamide (7, R = phenyl), two thionoamide (2, R = benzyl; 5,

A New Approach to Asymmetric Synthesis of Polycycles on the Basis of o-Quinodimethane Generation

The fluoride anion induced 1,4-elimination of 2-phenyl>-3,3-dimethyloxazolidinium salts generates (E,E)-α-alkyl-α'--o-quinodimethane intermediates, which are trapped stereoselectively with dienophiles to give polycycles.Intramolecular cyclization of 2-phenyl>-3,3-dimethyl-4-(R)-methyl-5(R)-phenyloxazolidinium triflate at 0 deg C produces a 3:1 diastereoisomeric mixture of 6--trans-octahydrophenanthrene, which is converted by hydrogenolysis on Pd/C to trans-octahydrophenanthrene with D +46.6 deg (50percent ee).Similarly, intramolecular cyclization of 2-phenyl>-3,3-dimethyl-4(S)-methoxymethyl-5(S)-phenyloxazolidinium triflate produces, after hydrogenolysis on Pd/C, trans-octahydrophenanthrene with D -51.1 deg (55percent ee).The enantioselection in the cycloaddition with o-quinodimethane intermediate may be accounted for on the basis of ?-stacking interaction in the Diels-Alder transition state.