1042149-07-4

Upstream product

• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 504-02-9 1,3-cylohexanedione 
• 50615-16-2 2-methyl-6,7-dihydro-5H-benzofuran-4-one 
• 108-90-7 chlorobenzene 
• 89530-34-7 1-phenyl-3-trimethylsilylprop-2-yn-1-ol 
• 705-60-2 (2-nitroprop-1-enyl)benzene 
• 93898-94-3 1-(3-Phenyl-propinoxy)-cyclohexen-⁽²⁾-on-⁽³⁾ 

Downstream Products

• 1131312-90-7 C₂₂H₂₁NO 

Relevant academic research and scientific papers

A calcium catalysed regioselective (5-exo dig) tandem process for the synthesis of fully substituted furans

An efficient and highly regio-selective synthesis of fused & substituted furans has been described using Ca(OTf)2 as the catalyst. This tandem process involves alkylation, 5-exo dig cyclisation and isomerization to furnish densely substituted f

Diversified Synthesis of Furans by Coupling between Enols/1,3-Dicarbonyl Compounds and Nitroolefins: Direct Access to Dioxa[5]helicenes

A versatile method for the diversified synthesis of furans and arenofurans has been developed that proceeds through K2CO3-promoted cyclization between enols/1,3-dicarbonyl compounds and nitroolefins at reflux in EtOH. This facile method has been successfully employed in the synthesis of benzotrifuran derivatives, which are useful hole-transporting materials. This procedure also provides direct access to dioxa[5]helicenes. This reaction offers a broad substrate scope, uses an inexpensive base and environmentally benign solvent, and is operationally simple.

Direct palladium-catalyzed C-4 arylation of tri-substituted furans with aryl chlorides: An efficient access to heteroaromatics

A series of functionalized furans were synthesized by way of a palladium -catalyzed coupling reaction of 2,3,5- trisubstituted furans with aryl chlorides through C-H bond cleavages at C-4 position. The feature of the reaction was facilitative preparation of furan derivatives with good functional group tolerance. All reactions gave the desired products in moderate to good yields in the presences of BuAd2P and t-BuOK in DMF at 120 °C after 15 h.

Pd-Catalyzed cyclization reaction: A convenient domino process for synthesis of α-carbonyl furan derivatives

The design and development of a new efficient two-step one pot protocol for the preparation of novel bicyclic a-carbonyl furans from readily accessible propargyl alcohols and commercially available 1,3-dicarbonyl compounds is presented. The reaction scope

Synthesis of 4-acetoxyindoles and related derivatives by means of air oxidation of 4-oxo-4,5,6,7-tetrahydroindoles obtained from nitroalkenes and cyclohexane-1,3-diones

A novel method for synthesizing 4-hydroxyindole derivatives from cyclohexane-1,3-diones and nitroalkenes have been developed in which a newly developed air oxidation of 4-oxo-4,5,6,7-tetrahydroindoles is playing a crucial role. Georg Thieme Verlag Stuttga

Sequential gold-catalyzed reactions of 1-phenylprop-2-yn-1-ol with 1,3-dicarbonyl compounds

A variety of sequential gold-catalyzed reactions of 1-phenylprop-2-yn-1-ol with 1,3-dicarbonyl compounds are directed towards different outcomes by a suitable choice of the catalytic system, feature of 1,3-dicarbonyl and reaction conditions.

Ruthenium/TFA-catalyzed coupling of activated secondary propargylic alcohols with cyclic 1,3-diones: Furan versus pyran ring formation

(Chemical Equation Presented) A catalytic system consisting of the 16-electron allyl-ruthenium(II) complex [Ru(η3-2-C 3H4Me)(CO)(dppf)][SbF6] (dppf = 1,1′-bis(diphenylphosphino)ferrocene) and trifluoroacetic acid (TFA) has been used to promote the coupling between secondary propargylic alcohols and cyclic 1,3-diketones. The nature of the resulting products was found to be dependent on the ring size of the dicarbonyl compound employed. Thus, whereas 6,7-dihydro-5H-benzofuran-4-ones have been selectively obtained starting from 1,3-cyclohexanediones, via furan-ring formation, the use of 1,3- cyclopentanedione leads instead to 6,7-dihydro-4H-cyclopenta[b]pyran-5-ones via a pyran-ring formation process.

FeCl3-catalyzed propargylation-cycloisomerization tandem reaction: A facile one-pot synthesis of substituted furans

An efficient FeCl3-catalyzed tandem propargylation- cycloisomerization reaction of propargylic alcohols or acetates with 1,3-dicarbonyl compounds, leading to the synthesis of substituted furans, has been developed. Georg Thieme Verlag Stuttgart