104225-07-2

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 77405-45-9 9-{(Z)-1-[(S)-(tert-Butyl-dimethyl-silanyloxy)-cyclohexyl-methyl]-propenyloxy}-9-bora-bicyclo[3.3.1]nonane 
• 78-84-2 isobutyraldehyde 
• 88155-25-3 C₂₄H₄₉BO₂Si 
• 80615-74-3 (S)-(-)-1-<(tert-Butyldimethylsilyl)oxy>-1-cyclohexylbutan-2-one 
• 131363-04-7 2-[(R)-Hydroxy-((4R,5R)-5-isopropyl-4-methyl-4,5-dihydro-isoxazol-3-yl)-methyl]-cyclohexanone 

Relevant academic research and scientific papers

VERY HIGH DIASTEREOFACIAL SELECTIVIES IN CONVENIENT TITANIUM-MEDIATED ALDOL REACTIONS

Very high (> 99percent) diastereofacial selectivities in aldol reactions of a chiral titanium enolate with a variety of aldehydes can be conveniently achieved.The ease of preparation of -Ti(OCHMe2)3 enolates, low cost, low toxicity, and ease of work-up make this a very useful method for synthesis of chirally pure substances.

syn- and anti-Selective Preparation of 3-Substituted-Δ2-Isoxazolines

Both syn- and anti- isomers of 3-substituted-Δ2-isoxazolines can be prepared in a stereoselective way by the aldol reaction of 3-formyl-Δ2-isoxazolines and silyl enol ethers in the presence of appropriate Lewis acid.

Asymmetric Aldol Reactions. A Titanium Enolate Giving Very High Diastereofacial Selectivities

Diastereofacial selectivities of 99percent can be conveniently obtained in aldol reactions of the chiral titanium enolate derived from the ketone C2H5COCH(OSiMe2-t-Bu)-c-C6H11, with representative aldehydes.The key to obtaining such selectivities is shown