VERY HIGH DIASTEREOFACIAL SELECTIVIES IN CONVENIENT TITANIUM-MEDIATED ALDOL REACTIONS

Article abstract of DOI:10.1016/S0040-4039(00)85504-5

Very high (> 99percent) diastereofacial selectivities in aldol reactions of a chiral titanium enolate with a variety of aldehydes can be conveniently achieved.The ease of preparation of -Ti(OCHMe2)3 enolates, low cost, low toxicity, and ease of work-up make this a very useful method for synthesis of chirally pure substances.