104253-47-6

Basic information

• Product Name: 5-AMino-2-chloro-4-Methoxy-benzoic acid Methyl ester
• Synonyms: 5-AMino-2-chloro-4-Methoxy-benzoic acid Methyl ester;Methyl 5-amino-2-chloro-4-methoxybenzoate
• CAS NO: 104253-47-6
• Molecular Formula: C₉H₁₀ClNO₃
• Molecular Weight: 215.6336
• Mol File: 104253-47-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 361.5±37.0 °C(Predicted)
• Appearance: /
• Density: 1.302±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.75±0.10(Predicted)
• CAS DataBase Reference: 5-AMino-2-chloro-4-Methoxy-benzoic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMino-2-chloro-4-Methoxy-benzoic acid Methyl ester(104253-47-6)
• EPA Substance Registry System: 5-AMino-2-chloro-4-Methoxy-benzoic acid Methyl ester(104253-47-6)

Safety Data

• Hazardous Substances Data: 104253-47-6(Hazardous Substances Data)

Upstream product

• 90537-46-5 methyl 2-chloro-4-methoxy-5-nitrobenzoate 
• 33458-99-0 2-chloro-4-methoxy-5-nitrobenzoic acid 
• 33458-98-9 2-chloro-4,5-dinitrobenzoic acid 

Downstream Products

• 1143025-71-1 potassium 5-amino-2-chloro-4-methoxybenzoate 
• 1143025-74-4 2-chloro-5-hydrazinyl-4-methoxybenzoic acid hydrochloride 
• 1143025-76-6 methyl 2-chloro-5-hydrazinyl-4-methoxybenzoate hydrochloride 
• 1143025-78-8 methyl 2-chloro-4-methoxy-5-(1H-pyrazol-1-yl)benzoate 
• 1143025-79-9 2-chloro-4-methoxy-5-(1H-pyrazol-1-yl)benzamide 
• 1143023-95-3 2-chloro-4-methoxy-N-(6-(3-(4-methylpiperazin-1-yl)propylsulfonyl)benzo[d]thiazol-2-ylcarbamoyl)-5-(1H-pyrazol-1-yl)benzamide 
• 1629269-87-9 methyl 5-acetamido-2-chloro-4-methoxybenzoate 
• 1629269-90-4 N-(4-chloro-2-methoxy-5-(1-methylcyclopropyl)phenyl)acetamide 
• 1629269-89-1 N-(4-chloro-2-methoxy-5-(prop-1-en-2-yl)phenyl)acetamide 
• 1629269-88-0 N-(4-chloro-5-(2-hydroxypropan-2-yl)-2-methoxyphenyl)acetamide 

Relevant articles and documents

Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists

Ghrelin plays a major physiological role in the control of food intake, and inverse agonists of the ghrelin receptor (GHS-R1a) are widely considered to offer utility as antiobesity agents by lowering the set-point for hunger between meals. We identified an acylurea series of ghrelin modulators from high throughput screening and optimized binding affinity through structure-activity relationship studies. Furthermore, we identified specific substructural changes, which switched partial agonist activity to inverse agonist activity, and optimized physicochemical and DMPK properties to afford the non-CNS penetrant inverse agonist 22 (AZ-GHS-22) and the CNS penetrant inverse agonist 38 (AZ-GHS-38). Free feeding efficacy experiments showed that CNS exposure was necessary to obtain reduced food intake in mice, and it was demonstrated using GHS-R1a null and wild-type mice that this effect operates through a mechanism involving GHS-R1a.