104267-07-4

Upstream product

• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 
• 104266-89-9 (S)-4-benzyl-3-phenylacetyl-2-oxazolidinone 
• 870-50-8 di-tert-butyl-diazodicarboxylate 
• 104266-95-7 (3(2S),4S)-3-{2-[N,N'-bis-(t-butoxycarbonyl)hydrazino]phenylacetyl}-4-(phenylmethyl)-2-oxazolidinone 
• 67-56-1 methanol 
• 186581-53-3 diazomethane 

Downstream Products

• 126191-14-8 methyl 2(R)-<<(+)-2-methoxy-2-(trifluoromethyl)-2-phenylacetyl>amino>-2-phenylacetate 
• 70363-21-2 2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)phenylacetic acid, methyl ester 

Relevant academic research and scientific papers

The Asymmetric Synthesis of α-Amino and α-Hydrazino Acid Derivatives via The Stereoselective Amination of Chiral Enolates with Azodicarboxylate Esters.

The utility of azodicarboxylate esters as (+)NH2 and (+)NH-NH2 synthons in highly diastereoselective reactions with chiral carboximide-derived enolates has been demonstrated.The lithium enolates derived from 4-substituted N-acyl 2-oxazolidinones were found to react with di-tert-butyl azodicarboxylate (DBAD) to afford the derived 2-hydrazido carboxylic acid derivetives in yields in excess of 90 percent.The diastereoselectivities of these reactions ranged from 97percent to greater than 99percent.The subsequent transformation of these adducts to both α-hydrazino and α-amino acids in enantiomeric purities in excess of 99percent is described.