104271-41-2

Basic information

• Product Name: CYCLOPROPYL 3-METHOXYPHENYL KETONE
• Synonyms: CYCLOPROPYL 3-METHOXYPHENYL KETONE;cyclopropyl(3-Methoxyphenyl)Methanone
• CAS NO: 104271-41-2
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.21
• Mol File: 104271-41-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 275.5°C at 760 mmHg
• Flash Point: 119.7°C
• Appearance: /
• Density: 1.142g/cm³
• Vapor Pressure: 0.00507mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: CYCLOPROPYL 3-METHOXYPHENYL KETONE(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOPROPYL 3-METHOXYPHENYL KETONE(104271-41-2)
• EPA Substance Registry System: CYCLOPROPYL 3-METHOXYPHENYL KETONE(104271-41-2)

Safety Data

• Hazardous Substances Data: 104271-41-2(Hazardous Substances Data)

Usage

General Description

CYCLOPROPYL 3-METHOXYPHENYL KETONE is an organic compound with the chemical formula C11H12O. It is a ketone with a cyclopropyl ring and a 3-methoxyphenyl group attached to it. CYCLOPROPYL 3-METHOXYPHENYL KETONE is used in the synthesis of various pharmaceuticals and organic compounds due to its reactivity and ability to undergo various chemical reactions. It serves as a versatile building block in organic chemistry, and its unique structural features make it valuable in the discovery and development of new drugs and biologically active molecules. Additionally, it is also used as an intermediate in the production of fragrances, flavors, and agrochemicals.

InChI:InChI=1/C11H12O2/c1-13-10-4-2-3-9(7-10)11(12)8-5-6-8/h2-4,7-8H,5-6H2,1H3

Upstream product

• 100-66-3 methoxybenzene 
• 5500-21-0 cyclopropropanecarbonitrile 
• 23719-80-4 cyclopropylmagnesium bromide 
• 152121-82-9 N,3‐dimethoxy‐N‐methylbenzamide 
• 586-38-9 3-Methoxybenzoic acid 
• 76106-47-3 cyclopropyl (3-hydroxyphenyl)methanone 
• 74-88-4 methyl iodide 

Downstream Products

• 104271-42-3 5,6-dihydro-8-(3-hydroxyphenyl)imidazo<1,2-a>pyridine 
• 104271-40-1 5,6-dihydro-8-(3-methoxyphenyl)imidazo<1,2-a>pyridine 
• 1355648-54-2 C₁₅H₁₈O₂ 

Relevant articles and documents

Regioselective, directed meta acylation of aromatic compounds

A new method for the directed meta acylation of aromatic compounds is described. This method involves an ortho lithiation procedure combined with zirconocene-benzyne chemistry. 3-Acyl-1-substituted benzene derivatives were obtained by acidic hydrolysis of the azazirconacycle intermediate which results from the coupling of a nitrile with a zirconocene-benzyne complex. Similarly, 3-acyl-2-iodo-1-substituted benzene derivatives were obtained by the iodination of the same intermediate followed by acidic hydrolysis. These procedures, which utilize simple, readily available starting materials, give good yields of regiochemically pure products.

Reactions of Aryl Cyclopropyl Ketones. A New Synthesis of Aryl Tetralones

Aryl cyclopropyl ketones (2) cyclise to 1-tetralones (3) in the presence of a variety of acid catalysts under mild conditions.Open-chain carbinols (4) are also formed.The ratio of (3) to (4) is dependent on the aryl ring substituents.A cationic mechanism is proposed.Cyclopropyl ketones (1) do not react.Stereoelectronic factors involved in the reactivity of the rigig cyclopropyl ketone (12) are discussed.The reactions of selected phenolic cyclopropyl ketones have been investigated as anionic counterparts to the acid-catalysed reactions.No reaction is observed.