104283-70-7

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 124-68-5 2-Amino-2-methyl-1-propanol 

Downstream Products

• 104778-46-3 5-fluoro-3-(5,6,7,8-tetrahydro-1-naphthalenyl)-1(3H)-isobenzofuranone 
• 71171-94-3 2-(4-Fluorophenyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 1093868-91-7 2-(2-bromo-4-fluorophenyl)-4,4-dimethyl-2-oxazoline 
• 104761-70-8 cis-10-fluoro-1,2,3,4,7,12-hexahydro-7,12-dimethylbenzanthracene-7,12-diol 
• 104761-65-1 trans-10-fluoro-1,2,3,4,7,12-hexahydro-7,12-dimethylbenzanthracene-7,12-diol 
• 104761-68-4 10-fluoro-1,2,3,4-tetrahydrobenzanthracen-7-ol acetate 
• 104761-71-9 7-(chloromethyl)-10-fluoro-1,2,3,4-tetrahydro-12-methylbenzanthracene 
• 104761-67-3 4-fluoro-2-<(5,6,7,8-tetrahydro-1-naphthalenyl)methyl>benzoic acid 
• 104761-69-5 10-fluoro-1,2,3,4-tetrahydrobenzanthracene-7,12-dione 
• 104761-45-7 10-fluoro-1,2,3,4-tetrahydro-7,12-dimethylbenzanthracene 

Relevant academic research and scientific papers

Directed functionalization of halophenyl-2-oxazolines with TMPMgCl?LiCl

A variety of difunctionalized aryl-2-oxazolines were prepared from the reaction of halophenyl-2-oxazolines and TMPMgCl?LiCl to give an organomagnesium reagent, which was then treated with various electrophiles. The metalation step takes place under mild conditions, and this process al-lows for the isolation of the desired products in good yields. No isomeric or other benzyne-derived products were detected. The influence of the halogen substituents on the acidity of the aromatic hydrogen atoms was evaluated by using density functional theory (DFT) calculations.