1042973-67-0

Basic information

• Product Name: 8-Amino-4H-1,4-benzoxazin-3-one
• CAS NO: 1042973-67-0
• Molecular Formula: C₈H₇ClN₂O₂
• Molecular Weight: 164.16132
• Mol File: 1042973-67-0.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-Amino-4H-1,4-benzoxazin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Amino-4H-1,4-benzoxazin-3-one(1042973-67-0)
• EPA Substance Registry System: 8-Amino-4H-1,4-benzoxazin-3-one(1042973-67-0)

Safety Data

• Hazardous Substances Data: 1042973-67-0(Hazardous Substances Data)

Upstream product

• 6358-08-3 4-chloro-6-nitro-2-aminophenol 
• 870064-73-6 6-chloro-8-nitro-2H-benzo[b][1,4]oxazin-3(4H)-one 

Downstream Products

• 1313588-07-6 C₂₂H₂₀Cl₂F₃N₅O₂ 
• 321126-82-3 8-amino-2H-benzo[b][1,4]oxazin-3(4H)-one 

Relevant articles and documents

Nanoscale Fe2O3-based catalysts for selective hydrogenation of nitroarenes to anilines

Production of anilines - key intermediates for the fine chemical, agrochemical, and pharmaceutical industries - relies on precious metal catalysts that selectively hydrogenate aryl nitro groups in the presence of other easily reducible functionalities. Herein, we report convenient and stable iron oxide (Fe2O3) - based catalysts as a more earth-abundant alternative for this transformation. Pyrolysis of iron-phenanthroline complexes on carbon furnishes a unique structure in which the active Fe2O 3 particles are surrounded by a nitrogen-doped carbon layer. Highly selective hydrogenation of numerous structurally diverse nitroarenes (more than 80 examples) proceeded in good to excellent yield under industrially viable conditions.

Optimization of triazoles as novel and potent nonphlorizin SGLT2 inhibitors

Previous efforts have led to the identification of a potent, selective, and nonphlorizin based SGLT2 inhibitor 1. This Letter describes efforts to further optimize the potency, microsomal stability, solubility and pharmacokinetic properties of this series of SGLT2 inhibitors. From these efforts, compounds 28 and 32 have improved solubility and pharmacokinetic properties compared to compound 1.

CONDENSED HETEROCYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I) wherein R1, A, B, D, E, G, Q, Ar, n, m, and p are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.