1042987-87-0

Usage

Derivative of indazole

Indazole is a heterocyclic aromatic organic compound 1H-INDAZOLE, 5-FLUORO-1-METHYL-3-PHENYL- is based on the indazole structure, which is a five-membered aromatic ring containing one nitrogen atom.

Structural features

Fluorine atom, methyl group, and phenyl ring The presence of these functional groups in the compound contributes to its versatility in synthesis and potential applications.

Versatile building block

Synthesis of various pharmaceutical and agrochemical compounds Due to its unique structure, 1H-INDAZOLE, 5-FLUORO-1-METHYL-3-PHENYL- can be used as a starting material for creating a wide range of other compounds in the pharmaceutical and agrochemical industries.

Potential applications in medicinal chemistry

Pharmacophore, development of new drug candidates The compound's structure can be used as a pharmacophore, which is a part of a molecule responsible for the biological activity of a drug. This makes it a valuable component in the development of new drug candidates with improved therapeutic potential.

Enhanced biological activity

Improved therapeutic potential The presence of the fluorine atom and other structural features may contribute to increased biological activity, leading to more effective drugs.

Uses in agricultural purposes

Development of new chemical entities The compound may also be used in the creation of new chemical entities for agricultural purposes, such as pesticides or herbicides.

Upstream product

• 459-59-6 4-fluoro-N-methylaniline 
• 937-25-7 N-(4-fluorophenyl)-N-(methyl)nitrous amide 
• 611-73-4 Benzoylformic acid 
• 98-86-2 acetophenone 
• 1978-54-7 1-(4-fluorophenyl)-1-methylhydrazine 
• 308805-77-8 1-(2-phenylethynyl)-1-cyclobutanol 
• 1260893-27-3 C₈H₆BrFN₂ 
• 98-80-6 phenylboronic acid 
• 591-50-4 iodobenzene 
• 1210023-65-6 5-fluoro-1-methyl-1H-indazole 

Downstream Products

• 1620816-79-6 5-fluoro-1-methyl-3-phenyl-7-p-tolyl-1H-indazole 

Relevant academic research and scientific papers

Rh(iii)-catalyzed, hydrazine-directed C-H functionalization with 1-alkynylcyclobutanols: A new strategy for 1: H -indazoles

Rh(iii)-catalyzed coupling of phenylhydrazines with 1-alkynylcyclobutanols was realized through a hydrazine-directed C-H functionalization pathway. This [4+1] annulation, based on the cleavage of a Csp-Csp triple bond in alkynylcyclobutanol, provides a new pathway to prepare diverse 1H-indazoles under mild reaction conditions. This journal is

Palladium-catalyzed ortho-acylation of N-Nitrosoanilines with α-oxocarboxylic acids: A convenient method to synthesize N-Nitroso ketones and indazoles

An efficient and mild protocol for regioselective synthesis of N-Nitroso aryl ketones by palladium-catalyzed direct acylation of arenes using N-Nitroso as directing groups is described. This reaction proceeded smoothly and could tolerate a variety of functional groups. Moreover, this chemistry offers a convenient access to a range of indazoles.

Palladium-catalyzed direct C7-arylation of substituted indazoles

A novel direct C7-arylation of indazoles with iodoaryls is described using Pd(OAc)2 as catalyst, 1,10-phenanthroline as ligand, and K 2CO3 as base in refluxing DMA. Direct C7-arylation of 3-substituted 1H-indazole containing an EWG on the arene ring gave the expected products in good isolated yields. In addition, a one-pot Suzuki-Miyaura/ arylation procedure leading to C3,C7-diarylated indazoles has been developed.