1210023-65-6 Usage
Description
5-Fluoro-1-methyl-1H-indazole is an organic compound with the chemical formula C9H8FN. It is a derivative of indazole, a bicyclic heterocycle commonly found in pharmaceuticals and agrochemicals. 5-Fluoro-1-methyl-1H-indazole is characterized by a fluorine atom at the 5-position and a methyl group at the 1-position of the indazole ring.
Used in Pharmaceutical Industry:
5-Fluoro-1-methyl-1H-indazole is used as a chemical intermediate for the development of new drugs with neurological and psychoactive effects. Its unique structure and properties make it a promising candidate for the creation of novel therapeutic agents.
Used in Medicinal Chemistry Research:
5-Fluoro-1-methyl-1H-indazole is used as a research compound for studying its potential as a cannabinoid receptor ligand. This makes it of interest for the development of new therapeutic drugs targeting the endocannabinoid system, which plays a crucial role in various physiological processes.
Used in Agrochemical Industry:
5-Fluoro-1-methyl-1H-indazole is used as a building block for the synthesis of agrochemicals, such as pesticides and herbicides. Its unique structure and properties can contribute to the development of more effective and environmentally friendly products.
As a Novel Chemical Entity:
5-Fluoro-1-methyl-1H-indazole is a novel chemical entity that requires further study to fully understand its properties and potential applications. Its unique structure and potential as a cannabinoid receptor ligand make it an exciting area of research for both the pharmaceutical and agrochemical industries.
Check Digit Verification of cas no
The CAS Registry Mumber 1210023-65-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,0,0,2 and 3 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1210023-65:
(9*1)+(8*2)+(7*1)+(6*0)+(5*0)+(4*2)+(3*3)+(2*6)+(1*5)=66
66 % 10 = 6
So 1210023-65-6 is a valid CAS Registry Number.
1210023-65-6Relevant articles and documents
Direct N-Alkylation and Kemp Elimination Reactions of 1-Sulfonyl-1H-Indazoles
Tang, Meng,Chu, Bingjie,Chang, Xiaowei
, p. 2109 - 2116 (2018/07/31)
The reactions of 1-sulfonyl-1H-indazoles under basic conditions are discussed, and the direct N-alkylation and Kemp elimination reactions of these compounds are reported. A series of 2-(p-tosylamino)benzonitriles and N-alkyl indazoles were prepared in good yields. Moreover, the 2-(p-tosylamino)benzonitriles could be transformed into a diverse range of important derivatives in a one-pot reaction. This method was successfully applied to the total syntheses of quindolinone and cryptolepinone; quindolinone was prepared in a one-pot reaction from 1-sulfonyl-1H-indazole.
Route design and development of a MET kinase inhibitor: A copper-catalyzed preparation of an N 1 - Methylindazole
Kallman, Neil J.,Liu, Chin,Yates, Matthew H.,Linder, Ryan J.,Ruble, J. Craig,Kogut, Eugene F.,Patterson, Lawrence E.,Laird, Dana L. T.,Hansen, Marvin M.
, p. 501 - 510 (2014/05/06)
The synthesis of a MET kinase inhibitor in an overall yield of 22% was achieved over eight steps starting with 3-hydroxybenzaldehyde, an improvement from the initial 12-step process with a 5.4% yield. Highlights of the process chemistry design and development are a Cu-catalyzed cyclization to form an important N1-methylindazole ring, a selective nitro reduction in the presence of an aryl bromide, a late-stage Suzuki cross-coupling, and a base-promoted Boc deprotection to form the desired drug candidate.