64750-24-9Relevant academic research and scientific papers
METHOD FOR SYNTHESIS OF LOBARIC ACID AND ANALOG THEREOF
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, (2021/08/13)
The present invention can synthesize lobaric acid and four analogues thereof, which are five phenolic lichen metabolites isolated from an extract of the Antarctic lichen Stereocaulon alpinum and selectively inhibit PTP1B, by a simple, economic and efficient chemical synthesis method.
Total Syntheses of Lobaric Acid and Its Derivatives from the Antarctic Lichen Stereocaulon alpinum
Kim, Tai Kyoung,Kim, Joung Eun,Youn, Ui Joung,Han, Se Jong,Kim, Il-Chan,Cho, Cheon-Gyu,Yim, Joung Han
, p. 1460 - 1467 (2018/06/29)
The first total syntheses of the natural products lobaric acid (1) and its derivatives isolated from the Antarctic lichen Stereocaulon alpinum are reported in this study. Lobarin (3), with a pseudodepsidone structure, was synthesized first in 11 steps by utilizing an Ullmann aryl ether coupling reaction, and lobaric acid was synthesized in an additional three steps by a seven-membered lactonization reaction. Various derivatives were also obtained from the prepared lobaric acid, and the synthetic compounds exhibited significant PTP1B inhibitory activities.
Synthesis of Further Lichen Depsides
Elix, John A.,Barclay, Caroline E.,David, Feeya,Griffin, Frank K.,Hill, Alison M.,et al.
, p. 301 - 313 (2007/10/02)
The unambiguous total synthesis of 18 lichen depsides has been achieved by the condensation of an appropriately substituted orsellinic acid and protected phenol in the key step, followed by subsequent deprotection and/or secondary reduction.The natural oc
