104316-13-4

Upstream product

• 13211-31-9 tert-butyl L-valinate 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 

Downstream Products

• 104316-15-6 (S)-ethyl cyclohexanone-2-(2,2-dicarbo-t-butoxy-ethyl)-2-carboxylate 
• 104316-14-5 (R)-ethyl cyclohexanone-2-(2,2-dicarbo-t-butoxy-ethyl)-2-carboxylate 
• 72763-87-2 ethyl (R)-1-(prop-2-enyl)-2-oxocyclohexanecarboxylate 
• 58648-10-5 ethyl (S)-1-allyl-2-oxocyclohexane-1-carboxylate 
• 116831-08-4 (R)-ethyl cyclohexanone-2-(2-carboethoxy-ethyl)-2-carboxylate 
• 116831-06-2 (S)-ethyl cyclohexanone-2-(2-carboethoxy-ethyl)-2-carboxylate 
• 862563-61-9 C₂₀H₂₂F₃NO₅S₂ 
• 862563-56-2 C₁₉H₂₁NO₃S 
• 862563-57-3 C₁₉H₂₃NO₂S 
• 862563-54-0 (2-benzenesulfonyl-1-methyl-cyclohex-2-enylmethyl)-furan-2-ylmethyl-amine 
• 862563-55-1 C₁₉H₂₁NO₃S 
• 862563-51-7 1-methyl-2-phenylsulfanyl-cyclohex-2-enecarboxylic acid ethyl ester 
• 862563-53-9 2-benzenesulfonyl-1-methyl-cyclohex-2-enecarbaldehyde 
• 862563-60-8 (1-methyl-2-phenylsulfanyl-cyclohex-2-enyl)-methanol 

Relevant academic research and scientific papers

Enantioselective approach to the hetisine alkaloids. Synthesis of the 3-methyl-1-aza-tricyclo[5.2.1.03,8]decane core via intramolecular dipolar cycloaddition

(Chemical Equation Presented) An efficient, enantioselective approach to the hetisine class of the C20-diterpenoid alkaloids is described. The strategy involves an intramolecular oxidopyridinium dipolar cycloaddition as the key transformation,

Stereoselective reactions. XXI. Asymmetric alkylation of α-alkyl β-keto esters to α,α-dialkyl β-keto esters having either (R)- Or (S)-chiral quaternary center depending on the solvent system

Asymmetric alkylation reaction of chiral enamines prepared from α-alkyl β-keto esters and (S)-valine tert-butyl ester leading to either enantiomer is described. Lithiated chiral enamines can be alkylated with alkyl halides in a toluene solvent in the presence of HMPA to give, after hydrolysis, α,α-dialkyl β-keto esters in 70-99%ee. The reactions in the presence of THF, dioxolane, or trimethylamine, instead of HMPA, afford the corresponding antipodes with enantiomeric purities of 44-92%ee. The present method provides a procedure for the synthesis of both enantiomers of α,α-dialkyl β-keto esters in high enantiomeric purities starting from the same chiral enamines.