116831-06-2Relevant articles and documents
Stereoselective Reactions. XXIV. Chlorotrimethylsilane Promoted Asymmetric Michael Reaction of Chiral Lithioenamines Derived from α-Alkyl β-Keto Esters
Ando, Kaori,Seo, Wonjun,Tomioka, Kiyoshi,Koga, Kenji
, p. 13081 - 13088 (1994)
Chlorotrimethylsilane promoted asymmetric Michael reaction of the chiral lithioenamines derived from α-alkyl β-keto esters and (S)-valine tert-butyl ester is described.Complementary asymmetric syntheses producing either enantiomers from the same starting
SUBSTITUTED SPIRO AZABICYCLICS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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Page/Page column 64-65, (2008/06/13)
The present application describes modulators of CCR3 of formula (Ia) and (Ib): (I) or pharmaceutically acceptable salt forms thereof, wherein Z, R1, R2, R3, R4, R5, R5', R6, a, b
Synthesis of optically active α,α-distubstituted β-keto esters via chiral β-enamino esters
Guingant,Hammami
, p. 411 - 414 (2007/10/02)
Michael addition of chiral β-enamino esters to MVK and acrylates promoted by Lewis acids (ZnCl2, MgBr2) or high pressure (11-14 Kbar) afforded, after hydrolytic work-up, α,α-disubstituted β-keto esters in good enantiomeric carbon exc
