104324-18-7

Basic information

• Product Name: N-(ISOTHIOCYANOACETYL)-(4R)-BENZYL-2-OXAZOLIDINONE
• Synonyms: N-(ISOTHIOCYANOACETYL)-(4R)-BENZYL-2-OXAZOLIDINONE;N-(ISOTHIOCYANOACETYL)-(4S)-BENZYL-2-OXAZOLIDINONE
• CAS NO: 104324-18-7
• Molecular Formula: C₁₃H₁₂N₂O₃S
• Molecular Weight: 276.31
• Mol File: 104324-18-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(ISOTHIOCYANOACETYL)-(4R)-BENZYL-2-OXAZOLIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(ISOTHIOCYANOACETYL)-(4R)-BENZYL-2-OXAZOLIDINONE(104324-18-7)
• EPA Substance Registry System: N-(ISOTHIOCYANOACETYL)-(4R)-BENZYL-2-OXAZOLIDINONE(104324-18-7)

Safety Data

• Hazardous Substances Data: 104324-18-7(Hazardous Substances Data)

Upstream product

• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 
• 104324-16-5 (4S)-(+)-3-(chloroacetyl)-4-(phenylmethyl)-2-oxazolidinone 
• 3182-95-4 L-Phenylalaninol 
• 63-91-2 L-phenylalanine 
• 75-15-0 carbon disulfide 
• 104324-17-6 (4S)-(+)-3-(azidoacetyl)-4-(phenylmethyl)-2-oxazolidinone 
• 463-71-8 thiophosgene 

Downstream Products

• 104324-19-8 (4S)-3-((4'S,5'R)-5'-((1R,3E)-1-methyl-3-pentenyl)-2'-thioxo-4'-oxazolidinylcarbonyl)-4-(phenylmethyl)-2-oxazolidinone 
• 218902-04-6 (4S,5R)-4-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-5-(3-chloro-4-fluoro-5-nitro-phenyl)-2-oxo-oxazolidine-3-carboxylic acid tert-butyl ester 
• 218902-02-4 (4S,5R)-4-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-5-(4-fluoro-3-nitro-phenyl)-2-oxo-oxazolidine-3-carboxylic acid tert-butyl ester 
• 357617-14-2 (4S)-4-benzyl-3-[(4S,5R)-1-[5-[3,4-bis(benzyloxy)-2-fluorophenyl]-2-thioxooxazolidin-4-yl]methanoyl]oxazolidin-2-one 
• 357617-15-3 (4S)-4-benzyl-3-[(4S,5R)-1-[5-[4,5-bis(benzyloxy)-2-fluorophenyl]-2-thioxooxazolidin-4-yl]methanoyl]oxazolidin-2-one 
• 218902-07-9 (S)-4-Benzyl-3-[(4S,5R)-5-(3-chloro-4-fluoro-5-nitro-phenyl)-2-thioxo-oxazolidine-4-carbonyl]-oxazolidin-2-one 
• 171738-37-7 (S)-4-Benzyl-3-[(4S,5R)-5-(4-fluoro-3-nitro-phenyl)-2-thioxo-oxazolidine-4-carbonyl]-oxazolidin-2-one 
• 104324-22-3 (4S)-3-<((4'S,5'R)-5'-methyl-2'-thioxo-4'-oxazolidinyl)carbonyl>-4-(phenylmethyl)-2-oxazolidinone 
• 104324-21-2 (S)-4-Benzyl-3-((4S,5R)-5-isopropyl-2-thioxo-oxazolidine-4-carbonyl)-oxazolidin-2-one 
• 104418-82-8 (4S)-3-((4'S,5'R)-5'-((1S,3E)-1-methyl-3-pentenyl)-2'-thioxo-4'-oxazolidinylcarbonyl)-4-(phenylmethyl)-2-oxazolidinone 
• 104324-23-4 (S)-4-Benzyl-3-((4S,5R)-5-phenyl-2-thioxo-oxazolidine-4-carbonyl)-oxazolidin-2-one 
• 143164-79-8 (S)-4-Benzyl-3-[(4S,5R)-5-(2-benzyloxy-5-bromo-phenyl)-2-thioxo-oxazolidine-4-carbonyl]-oxazolidin-2-one 
• 104324-20-1 (S)-4-Benzyl-3-[(4S,5R)-5-((E)-pent-3-enyl)-2-thioxo-oxazolidine-4-carbonyl]-oxazolidin-2-one 

Relevant articles and documents

Asymmetric Synthesis of (2S,3R) β-(4-F-3-NO2) phenyl Serine, D-(R)-4-methoxy-3,5-Bis tButyldimethylsiloxy Phenylglycine and Their Assemblage to C-O-D Ring of Vancomycin

The asymmetric synthesis of two appropriately functionalyzed non-proteinogenic amino acids 2 and 3 needed for the total synthesis of vancomycin was described.The assemblage of these amino acids into linear tripeptide followed by biary ether formation via intramolecular SNAr reaction led to the fully functionalized C-O-D ring vancomycin.