1043385-59-6

Basic information

• Product Name: 2,8,8-trimethyl-5-phenyl-5,7,8,9-tetrahydro-4H-chromeno[2,3-d]pyrimidine-4,6(3H)-dione
• CAS NO: 1043385-59-6
• Molecular Weight: 336.39
• Mol File: 1043385-59-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,8,8-trimethyl-5-phenyl-5,7,8,9-tetrahydro-4H-chromeno[2,3-d]pyrimidine-4,6(3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2,8,8-trimethyl-5-phenyl-5,7,8,9-tetrahydro-4H-chromeno[2,3-d]pyrimidine-4,6(3H)-dione(1043385-59-6)
• EPA Substance Registry System: 2,8,8-trimethyl-5-phenyl-5,7,8,9-tetrahydro-4H-chromeno[2,3-d]pyrimidine-4,6(3H)-dione(1043385-59-6)

Safety Data

• Hazardous Substances Data: 1043385-59-6(Hazardous Substances Data)

Upstream product

• 64-19-7 acetic acid 
• 107752-97-6 2-amino-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile 
• 108-24-7 acetic anhydride 

Relevant articles and documents

Synthesis of new 3H-chromeno[2,3-d]pyrimidine-4,6(5H,7H)-diones via the tandem intramolecular Pinner/Dimroth rearrangement

The reaction of 2-amino-4-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles with excess aliphatic carboxylic acids in the presence of phosphoryl chloride (POCl3) afforded new 2-alkyl-5-aryl-8,8-dimethyl-8,9-dihydro-3H-chromeno[2,3-d]pyrimidine-4,6(5H,7H)-diones in high yields. The suggested mechanism involves a tandem intramolecular Pinner/Dimroth rearrangement. The synthesized compounds were characterized by infrared (IR), proton nuclear magnetic resonance (1H NMR), carbon-13 nuclear magnetic resonance (13C NMR) and elemental analysis.