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Product FOB Price Min.Order Supply Ability Supplier
Bisoprolol fumarate
Cas No: 104344-23-2
USD $ 420.0-420.0 / Gram 100 Gram 500 Kilogram/Month Beijing Mesochem Technology Co.,LTD Contact Supplier
Bisoprolol fumarate Manufacturer/High quality/Best price/In stock
Cas No: 104344-23-2
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
Bisoprolol fumarate
Cas No: 104344-23-2
No Data 1 Kilogram 10 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
High quality Bisoprolol Hemifumarate supplier in China
Cas No: 104344-23-2
No Data No Data No Data Simagchem Corporation Contact Supplier
Bisoprolol fumarate
Cas No: 104344-23-2
No Data 1 Kilogram 100 Kilogram/Month HENAN SUNLAKE ENTERPRISE CORPORATION Contact Supplier
Hot sale 104344-23-2 Bisoprolol fumarate with best price
Cas No: 104344-23-2
USD $ 1000.0-1500.0 / Kilogram 1 Kilogram 100 Metric Ton/Month Crovell Biotech (Hebei) Co., Ltd. Contact Supplier
TIANFUCHEM--104344-23-2--High purity Bisoprolol fumarate in stock
Cas No: 104344-23-2
USD $ 2000.0-2000.0 / Metric Ton 1 Metric Ton 1000 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier
China Manufacturer Bisoprolol fumarate CAS 104344-23-2 Powder
Cas No: 104344-23-2
No Data 10 Metric Ton 2 Metric Ton/Day Hubei XinRunde Chemical Co., Ltd Contact Supplier
Bisoprolol fumarate CAS NO.104344-23-2
Cas No: 104344-23-2
USD $ 1000.0-1000.0 / Kilogram 1 Kilogram 100 Gram/Day Weifang Tansen Yiang international trading co., LTD Contact Supplier
Bisoprolol fumarate CAS 104344-23-2 Powder for antihypertensive
Cas No: 104344-23-2
No Data No Data 12 Kilogram/Day Hubei Jusheng Technology Co., Ltd., Contact Supplier

104344-23-2 Usage

Drug interactions

1.when bisoprolol fumarate is used in combination with other anti-hypertensive drugs, the antihypertensive effect is enhanced .
2. when bisoprolol fumarate is used in combination with reserpine, methyldopa, clonidine or guanfacine, the heart rate can be slowed down.
3. when bisoprolol fumarate is used in combination with reserpine, reserpine needs to be stopped a few days after stop of this product .
4. when bisoprolol fumarate is used in combination with nifedipine, the antihypertensive effect of this product can be enhanced .
5. when bisoprolol fumarate is used in combination with verapamil or diltiazem ketones calcium icon antagonists or other antiarrhythmic drugs , there is the need for patient care, because they can cause hypotension, bradycardia and others.

Uses

semi-synthetic kanamycin-derived aminoglycoside antibiotic

Uses

A selective a-adrenergic blocker. Used as an antihypertensive

Method and Dosage

Hypertension: The initial dose is 5mg once, 1 times a day. It may be suitable for some patients to start with initial dose of 2.5mg (such as bronchial spasm disease). If the dose of 5 mg one day is not enough for antihypertensive effect , the dose may be increased to 10-20mg one day .
Angina: initial dose of 2.5mg, 1 time a day, the maximum daily dose can not exceed 10mg.
Heart failure: chronic, stable heart failure: it should start from small dose, if it is tolerated, the dose can gradually increasing (doubling the dose every 2-4 weeks) to the maximum tolerated dose or target dose. The maximum recommended target dose is 10mg one day , the starting dose is usually 1/8 of the target dose.

Uses

antiinflammatory

Uses

A selective β-adrenergic blocker. Used as an antihypertensive.

Uses

A selective α-adrenergic blocker. Used as an antihypertensive.

Distinguish

Take appropriate amount of this product powder (about the equivalent of bisoprolol fumarate 20mg), add 4ml water to dissolve, the filtrate is added 1 to 3 drops of potassium permanganate test solution , purple should fade , and brown precipitate forms.
Take right amount of this product powder,it is dissolved in water and form the solution of which 1ml each contains about 0.1mg bisoprolol fumarate,after filtration, take continued filtrate, according to the UV-visible spectrophotometry (Appendix Ⅳ A) measure ,there is the maximum absorption in the 271nm wavelength.
In the chromatogram recorded under the item of content determination ,the test solution peak retention time should be consistent with the reference solution peak retention time.

Indications

Treatment of essential hypertension. As first-line antihypertensive agents, it can be used alone or combined with diuretics and vasodilator drugs.
Angina and myocardial infarction.
Arrhythmias, such as the rapid ventricular arrhythmia, ventricular contraction.
In recent years, bisoprolol fumarate is also tempted used for the treatment of heart failure. It is effective for moderate to severe chronic stable heart failure which previously receiving ACE inhibitors, diuretics and cardiac glycosides medications associated with ventricular systolic dysfunction (ejection fraction ≤35%) .
The above information is edited by the chemicalbook of Tian Ye.

Storage Characteristics

Treasury temperature, ventilation, dry

Content Determine

Take 10 tablets of this product , weigh accurately, porphyrize, accurately weigh appropriate amount (about the equivalent of bisoprolol fumarate 5mg), set it into 50ml volumetric flask, add water to make bisoprolol fumarate dissolve and dilute it to the mark , shake, filtrate, according to chromatographic conditions under the item of bisoprolol fumarate related substances,take the precise amount of continued filtrate 20μl into the liquid chromatograph, record the chromatograms; in addition , precisely weigh appropriate amount of the reference bisoprolol fumarate , dissolve it in water and dilute into the solution of which 1ml each contains about 0.1mg,measure in the same method, calculate according to the external standard method bisoprolol peak area ,it is obtained .

Toxicity

Moderate poisoning

Pharmacological effects

Bisoprolol fumarate is a selective β1-adrenergic receptor blockers. No intrinsic sympathomimetic activity and membrane stabilizing effect. Animal experiments of different models show that affinity for β1-receptor is 11 to 34-fold larger than β2-receptor. The selectivity for β1 receptor is four times of the similar drugs Atenolol. This product plays the role for a long time (24 hours or more), continual application takes good control of symptoms without tolerance phenomenon, with minimal side effects on the respiratory system, no effects on metabolism of fat. it also has a certain degree of block effect for bronchial β2 receptors, but it may only occur at high doses, usually it has no obvious clinical significance.

Flammability hazard characteristics

Combustible; fire decomposition with toxic nitrogen oxide fumes

Category

Toxic substances

Extinguishing agent

Water, carbon dioxide, dry, sandy soil

Chemical Properties

White Solid

Brand name

Zebeta (Duramed).

Precautions

Diabetic patients with great blood glucose fluctuations or acidosis patients should be careful in use of it.
Patients with pulmonary insufficiency, severe liver and kidney dysfunction should use with caution.
Interruption of treatment should diminish doses daily ,when it is used in combination with other antihypertensive drugs, the dose often requires reductions.
when drug overdose causes slow heartbeat or low blood pressure , patients must immediately stop taking this product. If necessary, take separate or sequential use of following drugs, atropine 0.5mg~2.0mg intravenously, appropriate amount of metaproterenol slow intravenous injection; glucagon 1mg~5mg (or 1mg~10mg).
Because the antihypertensive effect of bisoprolol fumarate, capacity of the patient to drive or operate the machine may be weakened , particularly at the beginning of taking medication or conversion medication and taking with alcohol at the same time, but the person's ability to respond will not be directly affected .

Side effects

1.In early medication, mild fatigue, chest tightness, dizziness, bradycardia, drowsiness, palpitations, headache and lower limb edema may appear , and all automatically reduce or disappear after continuing taking .
2. In rare cases, there will be gastrointestinal disorders (diarrhea, constipation, nausea, abdominal pain) and skin reactions (eg erythema, itching).
3. Occasionally blood pressure decreases , pulse slow or atrioventricular conduction disorders.
4.Sometimes there will be tingling or cold extremities, in rare cases, it can cause muscle weakness, muscle cramps and less tears.
5.For patients with intermittent claudication or Raynaud's phenomenon,during the initial medication, the condition may worsen, the condition of existing myocardial dysfunction patients will possibly aggravate.
6.Occasionally airway resistance may increase .
7.Elderly patients with diabetes, their glucose tolerance may reduce , which may cover hypoglycemia manifestations (such as rapid heartbeat).

Uses

Labeled Bisoprolol, intended for use as an internal standard for the quantification of Bisoprolol by GC- or LC-mass spectrometry.

Acute toxicity

Oral-rat LD50: 940 mg/kg; Oral-Mouse LD50: 678 mg/kg

Biological Activity

A selective β 1 -adrenergic antagonist. Has a K d of 2-3 nM at the β 1 receptor and a β 1 / β 2 selectivity of approximately 100-fold.
InChI:InChI=1/C18H31NO4.C4H4O4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

104344-23-2 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (B2185)  Bisoprolol hemifumarate salt  ≥98% (HPLC), solid 104344-23-2 B2185-10MG 1,419.21CNY Detail
USP (1075757)  Bisoprolol fumarate  United States Pharmacopeia (USP) Reference Standard 104344-23-2 1075757-200MG 4,662.45CNY Detail
Alfa Aesar (H56014)  Bisoprolol hemifumarate salt, 98%    104344-23-2 100mg 6049.0CNY Detail
Alfa Aesar (H56014)  Bisoprolol hemifumarate salt, 98%    104344-23-2 25mg 2160.0CNY Detail

104344-23-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name bisoprolol fumarate

1.2 Other means of identification

Product number -
Other names Well-bi

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:104344-23-2 SDS

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SummaryIn the present study, the compatibility between bisoprolol fumarate and selected excipients (ascorbic acid, citric acid anhydrous, butylated hydroxyanisole, polyvinylpyrrolidone, glycerol, mannitol and sorbitol) in mixtures (1:10 ratio of drug and excipient) was investigated by subjecting...detailed

The Maillard reaction of Bisoprolol fumarate (cas 104344-23-2) with various reducing carbohydrates08/04/2019

HPLC analysis of drug products containing bisoprolol fumarate and lactose revealed the presence of N-formylbisoprolol, which is a final product of the Maillard reaction. Formulations containing secondary amines and reducing carbohydrates are prone to the condensation of amine and carbonyl functi...detailed

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