104347-13-9

Basic information

• Product Name: (R)-(+)-alpha-Amino-gamma-butyrolactone hydrochloride
• Synonyms: (R)-(+)-2-AMINO-4-BUTYROLACTONE HYDROCHLORIDE;(R)-2-AMINO-4-BUTYROLACTONE HYDROCHLORIDE;(R)-(+)-ALPHA-AMINO-GAMMA-BUTYROLACTONE HYDROCHLORIDE;H-D-HSE-LACTONE HCL;D-HOMOSERINE LACTONE HYDROCHLORIDE;(R)-(+)-a-Amino-g-butyrolactone hydrochloride;R(+)alpha Amino-y Butyrolactone Hydrochloride;(R)-(+)-α-amino-γ-butyrolactonehydrochloride
• CAS NO: 104347-13-9
• Molecular Formula: C₄H₇NO₂*ClH
• Molecular Weight: 137.56
• Product Categories: Amino Lactones;Amino Acid Derivatives;Peptide Synthesis
• Mol File: 104347-13-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 220-224 °C
• Boiling Point: 257.1 °C at 760 mmHg
• Flash Point: 120.1 °C
• Appearance: Yellow to brown/Powder, Solid or Crystalline Powder
• Vapor Pressure: 0.0148mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility: Soluble in water
• CAS DataBase Reference: (R)-(+)-alpha-Amino-gamma-butyrolactone hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-alpha-Amino-gamma-butyrolactone hydrochloride(104347-13-9)
• EPA Substance Registry System: (R)-(+)-alpha-Amino-gamma-butyrolactone hydrochloride(104347-13-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 104347-13-9(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

InChI:InChI=1/C4H7NO2.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H/t3-;/m1./s1

Upstream product

• 348-67-4 D-methionine 
• 500720-04-7 α-Phenylacetamido-γ-Butyrolactone 
• 79-11-8 chloroacetic acid 
• 42417-39-0 (RS)-α-amino-γ-butyrolactone hydrochloride 
• 104347-03-7 2-Amino-4-(2-methoxy-ethoxymethoxy)-butyric acid methyl ester 

Downstream Products

• 67198-86-1 (R)-2-[(tert-butoxycarbonyl)amino]butano-4-lactone 
• 1020169-49-6 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)-N-[(3R)-2-oxotetrahydro-3-furanyl]benzamide 
• 1133869-85-8 N-(3-oxo-12-phenyldodecanoyl)-D-homoserine lactone 
• 878627-20-4 N-(3-oxo-6-phenylhexanoyl)-L-homoserine lactone 
• 939416-99-6 C₂₅H₂₀ClF₄N₃O₃ 
• 939417-63-7 C₂₅H₂₀ClF₄N₃O₃ 
• 152833-54-0 N-oxo-dodecanoyl-L-homoserine lactone 
• 1030851-60-5 (R)-(+)-N-heptanoylhomoserine lactone 
• 6027-21-0 D-homoserine 

Relevant articles and documents

Optical resolution by preferential crystallization of (RS)-α-amino-γ-butyrolactone hydrochloride

(RS)-α-Amino-γ-butyrolactone hydrochloride [(RS)-ABL·HCl] was found to exist as a conglomerate based on the infrared spectrum, solubility, and melting point. Optical resolution by preferential crystallization of (RS)-ABL·HCl was achieved to yield (R)- and (S)-ABL·HCl. The obtained (R)- and (S)-ABL·HCl were recrystallized, taking into account the solubility of (RS)-ABL·HCl to give optically pure (R)- and (S)-ABL·HCl.

Preparation method of high-optical-purity D- or L-selenomethionine

The invention discloses a preparation method of high-optical-purity D- or L-selenomethionine. The preparation method comprises the following steps: by taking D- or L-methionine as initial raw materials and diethyl sulfate or halogenated alkyl acid or derived esters as alkylation reagents, generating sulfonium salt, desulfurizing and closing ring under acidic conditions, to produce alpha-amino-gama-butyrolactone halate, having addition reaction to alpha-amino-gama-butyrolactone halate with methyl selenol salt and opening ring, acidifying with organic acid, and recrystallizing to obtain D- or L-selenomethionine. The chemical purity of the product is more than or equal to 99%, and the high optical purity is more than or equal to 99%. The preparation method is low-cost and easily available in raw materials, simple in steps and easy to operate, simple in reaction conditions, and suitable for large-scale production.

A new stereocontrolled approach to a key intermediate in the synthesis of (25,3R)-capreomycidine

A new stereocontrolled approach to the synthesis of advanced intermediate in the synthesis of nonproteinogenic amino acid (2S,3R)-capreomycidine via the novel domino reaction has been developed.