42417-39-0

Basic information

• Product Name: DL-Homoserine Lactone hydrochloride
• Synonyms: DL-Homoserine Lactone hydrochloride;3-Aminodihydrofuran-2(3H)-one hydrochloride;2(3H)-Furanone, 3-aminodihydro-, hydrochloride;3-aminooxolan-2-one hydrochloride
• CAS NO: 42417-39-0
• Molecular Formula: C₄H₇NO₂*ClH
• Molecular Weight: 137.56482
• Mol File: 42417-39-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 201-203 °C
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: DL-Homoserine Lactone hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: DL-Homoserine Lactone hydrochloride(42417-39-0)
• EPA Substance Registry System: DL-Homoserine Lactone hydrochloride(42417-39-0)

Safety Data

• Hazardous Substances Data: 42417-39-0(Hazardous Substances Data)

Usage

General Description

DL-Homoserine lactone hydrochloride is a chemical compound that is commonly used in laboratory research as a quorum sensing molecule and a signaling molecule in bacteria. It is also known for its role in bacterial communication and regulating gene expression. DL-Homoserine lactone hydrochloride is a synthetic form of the natural bacterial signaling molecule and is often used in laboratory experiments to study quorum sensing and related bacterial behaviors. It is especially important in understanding bacterial communication and can be used to study biofilm formation, virulence, and pathogenicity, making it an important tool for researchers in the field of microbiology.

Upstream product

• 1927-25-9 DL-Homoserine 
• 5061-21-2 α-bromo-γ-butyrolactone 
• 79-11-8 chloroacetic acid 
• 59-51-8 DL-methionine 
• 1192-20-7 2-aminobutyrolactone 
• 189334-61-0 3-(2,2-diphenylhydrazino)dihydro-2(3H)-furanone 

Downstream Products

• 137173-46-7 N-dodecanoyl-DL-homoserine lactone 
• 1071479-74-7 N-tridecanoyl-homoserine lactone 
• 18725-18-3 N-tetradecanoyl homoserine lactone 
• 36603-83-5 5-Chloro-dihydro-2(3H)-furanone 
• 50768-69-9 5-hydroxydihydrofuran-2(3H)-one 
• 25600-25-3 α-methoxy-γ-butyrolactone 
• 497-23-4 2-buten-4-olide 
• 4508-99-0 methyl γ-hydroxycrotonate 
• 96-48-0 4-butanolide 
• 1257107-40-6 4-[3-((R)-1-Naphthalen-1-yl-ethylamino)-propyl]-N-((R)-2-oxo-tetrahydro-furan-3-yl)-benzamide 
• 59-51-8 DL-methionine 
• 912452-05-2 C₁₅H₁₇NO₄ 
• 104347-13-9 (R)-(+)-α-amino-γ-butyrolactone hydrochloride 
• 2185-03-7 L-homoserine lactone hydrochloride 

Relevant articles and documents

Synthetic method for glufosinate ammonium

The invention relates to a synthetic method for glufosinate ammonium. The synthetic method comprises the following steps: single-bromine substitution, amination, amino protection, chlorination ring opening, Arbuzov reaction and acidizing hydrolysis ammoniation; the single-bromine substitution means triggering alpha-site single-bromine substitution betweengamma-butyrolactone I and bromine under theexistence of catalyst and performing reduced pressure distillation, thereby acquiring a pure intermediate II alpha-bromine-gamma-butyrolactone; phosphorus tribromide is served as the catalyst; amination means triggering amination reaction between alpha-bromine-gamma-butyrolactone II and ammonium hydroxide, and then adding hydrochloric acid and reflowing, thereby acquiring an intermediate IIIalpha-amino-gamma-butyrolactone hydrochloride. The invention has the beneficial effects: 1) low-costgamma-butyrolactone is taken as a raw material, is subjected to single-bromine substitution with bromineand then is subjected to amination reaction with ammonium hydroxide; the adopted raw materials are low-cost and easily acquired; reaction conditions are mild; operation is simple and convenient; safety is high; amplifying production is feasible; reaction yield is high; product purity is high; cost is greatly lowered; the synthetic method is suitable for industrial production.

Synthesis method of 2-amino-gamma-butyrolactone hydrochloride

The invention discloses a synthesis method of 2-amino-gamma-butyrolactone hydrochloride (I) for a kind of important chemical, dye, pesticide and medical intermediates. The synthesis method includes the following steps: taking a gamma-butyrolactone compound (II) and a nitroso ester compound (III) as raw materials to react with each other to obtain 2-(hydroxyl imino)-gamma-butyrolactone (IV), and subjecting the compound (IV) to reduction reaction and acidification to obtain the 2-amino-gamma-butyrolactone hydrochloride (I). The method used for preparing the product compound (I) is mild in condition, simple to operate, high in yield, low in environmental pollution, easier for industrial production and the like.

Preparation of α-(2,2-diphenylhydrazino)- and α-(benzyloxyamino)-lactones by radical cyclization: Use of glyoxylic acid diphenylhydrazone and glyoxylic acid 0-benzyloxime

Glyoxylic acid diphenylhydrazone (2, Y = NPh2) and the corresponding O-benzyloxime (2, Y = OBn) are easily esterified in high yield by β-bromo alcohols, and the resulting esters undergo radical cyclization to α-(2,2-diphenylhydrazino) or α-(ben